Mouse Anti-CST6 Monoclonal Antibody – Cat# MBS8102816

CST6 Antibody – Mouse Monoclonal

Name: CST6 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8102816
Price: 470 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8102816

Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an… More details

$470 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CST6, Monoclonal Antibody

Full Product Name

Anti-CST6 Antibody (HRP), Mouse Monoclonal

Product Gene Name

anti-CST6 antibody

Product Synonym Names

Cystatin E/CST6 Antibody (HRP), Mouse MAb; cystatin E/M

Clonality

Monoclonal

Isotype

Mouse IgG2a

Clone Number

4E7C10B7

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid; 0.2um filtered solution in PBS

Purity/Purification

Protein A

Specificity

Human Cystatin-M/Cystatin-E/CST6

Preparation and Storage

This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles.

Molecular Weight

16,511 Da

OMIM

601891

3D Structure

ModBase 3D Structure for Q15828

Immunogen

Recombinant Human CST6 protein

Conjugation

HRP

Preparation

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cystatin-M/CST6 (rh Cystatin-M). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP).

Applications Tested/Suitable for anti-CST6 antibody

ELISA (EIA)

Application Notes for anti-CST6 antibody

ELISA: 0.1-1ug/ml

Product References and Citations for anti-CST6 antibody

Ritonja A., et al., (1985), Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver. Biochem. Biophys. Res. Commun. 131:1187-1192.Pennacchio L.A., et al., (1996), Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).Science 271:1731-1734.Ghaemmaghami S., et al., (2003), Global analysis of protein expression in yeast.Nature 425:737-741.

Other Notes

Small volumes of anti-CST6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CST6 purchase

MBS8102816 is an antibody targeting CST6. Also known as Anti-CST6 Antibody (HRP), Mouse Monoclonal. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CST6. It may not necessarily be applicable to this product.

NCBI GI #

4503113

NCBI GeneID

1474

NCBI Accession #

NP_001314.1

UniProt Primary Accession #

Q15828

UniProt Secondary Accession #

Q540N7

UniProt Related Accession #

Q15828

GenBank Nucleotide #

NM_001323.3

NCBI Official Full Name

cystatin-M

NCBI Official Synonym Full Names

cystatin E/M

NCBI Official Symbol

CST6

UniProt Protein Name

Cystatin-M

UniProt Synonym Protein Names

Cystatin-6; Cystatin-E

Protein Family

ATF/CREB activator

UniProt Gene Name

CST6

UniProt Entry Name

CYTM_HUMAN

NCBI Protein Information

cystatin-M; cystatin 6; cystatin M; cystatin M/E; cystatin-6; cystatin-E; cysteine proteinase inhibitor

NCBI Summary for CST6

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

UniProt Comments for CST6

CST6: Shows moderate inhibition of cathepsin B but is not active against cathepsin C. Belongs to the cystatin family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cornified envelope

Molecular Function: cysteine protease inhibitor activity

Biological Process: anatomical structure morphogenesis; epidermis development

Research Articles on CST6

1. Low CST6 expression is associated with breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CST6 antibody

Reference Product	PubMed Publications
CSTB antibody	>3 publications with CST6 and CSTB
TGM3 antibody	>2 publications with CST6 and TGM3
LGMN antibody	>2 publications with CST6 and LGMN
CSTA antibody	>1 publications with CST6 and CSTA
CTSS antibody	>1 publications with CST6 and CTSS
LOR antibody	>1 publications with CST6 and LOR

Diseases associated with anti-CST6 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>25 publications with CST6 and Breast Neoplasms
Carcinoma Antibodies	>23 publications with CST6 and Carcinoma
Brain Diseases Antibodies	>5 publications with CST6 and Brain Diseases
Lung Neoplasms Antibodies	>4 publications with CST6 and Lung Neoplasms
Inflammation Antibodies	>3 publications with CST6 and Inflammation
Neoplasms, Experimental Antibodies	>3 publications with CST6 and Neoplasms, Experimental
Carcinoma, Squamous Cell Antibodies	>3 publications with CST6 and Carcinoma, Squamous Cell
Disease Models, Animal Antibodies	>3 publications with CST6 and Disease Models, Animal
Lung Diseases Antibodies	>3 publications with CST6 and Lung Diseases
Liver Neoplasms Antibodies	>2 publications with CST6 and Liver Neoplasms

Organs/Tissues associated with anti-CST6 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>13 publications with CST6 and Skin
Lymph Node Antibodies	>5 publications with CST6 and Lymph Node
Uterus Antibodies	>5 publications with CST6 and Uterus
Lung Antibodies	>4 publications with CST6 and Lung
Brain Antibodies	>4 publications with CST6 and Brain
Thyroid Antibodies	>2 publications with CST6 and Thyroid
Prostate Antibodies	>2 publications with CST6 and Prostate
Pancreas Antibodies	>1 publications with CST6 and Pancreas