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DARC Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS603001

Duffy Antigen Receptor for Chemokines (DARC), also known as Fy glycoprotein and CD234, is a 7TM non-signaling chemokine receptor that is expressed on venular endothelial cells and erythrocytes. DARC binds and mediates the internalization of several… More details

$1030 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DARC, Monoclonal Antibody
Full Product Name
DARC (Duffy Antigen, Fy Glycoprotein, GpFy, Cell Adhesion Molecule 3, CADM3)
Product Gene Name
anti-DARC antibody
Product Synonym Names
Anti -DARC (Duffy Antigen, Fy Glycoprotein, GpFy, Cell Adhesion Molecule 3, CADM3)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H31
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human DARC.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
35,553 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (159173803..159176290). Location: 1q21-q22
OMIM
110700
3D Structure
ModBase 3D Structure for Q16570
Immunogen
HEK293 cells transfected with human DARC, Accession # CAA59770

Product Categories/Family for anti-DARC antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-DARC antibody
ELISA (EL/EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-DARC antibody
Suitable for use in Flow Cytometry and ELISA.
Dilution: Flow Cytometry: 25ug/ml

Other Notes

Small volumes of anti-DARC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DARC purchase

MBS603001 is an antibody targeting DARC. Also known as DARC (Duffy Antigen, Fy Glycoprotein, GpFy, Cell Adhesion Molecule 3, CADM3). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DARC. It may not necessarily be applicable to this product.

NCBI GI #
171846251
NCBI GeneID
2532
NCBI Accession #
NP_001116423.1
UniProt Primary Accession #
Q16570
UniProt Secondary Accession #
O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1; A8YPG5
UniProt Related Accession #
Q16570
GenBank Nucleotide #
NM_001122951.2
NCBI Official Full Name
Duffy antigen/chemokine receptor isoform a
NCBI Official Synonym Full Names
Duffy blood group, atypical chemokine receptor
NCBI Official Symbol
DARC
NCBI Official Synonym Symbols
FY; Dfy; GPD; GpFy; ACKR1; CCBP1; CD234; WBCQ1
UniProt Protein Name
Duffy antigen/chemokine receptor
UniProt Synonym Protein Names
Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor
Protein Family
Darcynin
UniProt Gene Name
DARC
UniProt Synonym Gene Names
FY; GPD; GpFy
UniProt Entry Name
DUFFY_HUMAN
NCBI Protein Information
Duffy antigen/chemokine receptor; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; atypical chemokine receptor 1; Duffy blood group, chemokine receptor

NCBI Summary for DARC

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for DARC

DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, Duffy family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: recycling endosome; early endosome; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; transmembrane receptor activity; C-C chemokine binding; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; defense response; inflammatory response; regulation of chemokine production

Disease: White Blood Cell Count Quantitative Trait Locus 1; Blood Group, Duffy System; Malaria, Susceptibility To
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Research Articles on DARC

1. co-expression of DARC, D6, and CCX-CKR significantly associated with higher survival in gastric cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DARC antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-DARC antibody

 Disease Name  Pubmed Publications
 Malaria Antibodies  >69 publications with DARC and Malaria
 Inflammation Antibodies  >39 publications with DARC and Inflammation
 Neoplasms Antibodies  >34 publications with DARC and Neoplasms
 Death Antibodies  >23 publications with DARC and Death
 Cardiovascular Diseases Antibodies  >22 publications with DARC and Cardiovascular Diseases
 Heart Diseases Antibodies  >15 publications with DARC and Heart Diseases
 Necrosis Antibodies  >10 publications with DARC and Necrosis
 Carcinoma Antibodies  >8 publications with DARC and Carcinoma
 Acute Lung Injury Antibodies  >7 publications with DARC and Acute Lung Injury
 Kidney Diseases Antibodies  >7 publications with DARC and Kidney Diseases

Organs/Tissues associated with anti-DARC antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >39 publications with DARC and Vascular
 Heart Antibodies  >24 publications with DARC and Heart
 Lung Antibodies  >23 publications with DARC and Lung
 Kidney Antibodies  >18 publications with DARC and Kidney
 Brain Antibodies  >10 publications with DARC and Brain
 Eye Antibodies  >7 publications with DARC and Eye
 Bone Antibodies  >5 publications with DARC and Bone
 Pharynx Antibodies  >3 publications with DARC and Pharynx
 Placenta Antibodies  >2 publications with DARC and Placenta
 Uterus Antibodies  >1 publications with DARC and Uterus
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