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anti-DCN antibody :: Mouse anti-Human Decorin Monoclonal Antibody

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Catalog # MBS606237
Unit / Price
  0.5 mg  /  $760 +1 FREE 8GB USB
anti-DCN antibody
Product Name

Decorin (DCN), Monoclonal Antibody

Also Known As

Decorin (DCN, Bone Proteoglycan II, CSCD, DSPG2, PG40, PGII, PGS2, Small Leucine Rich Protein 1B, SLRR1B)

Product Synonym Names
Anti -Decorin (DCN, Bone Proteoglycan II, CSCD, DSPG2, PG40, PGII, PGS2, Small Leucine Rich Protein 1B, SLRR1B)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (91539035..91576806, complement). Location: 12q21.33
OMIM
125255
3D Structure
ModBase 3D Structure for P07585
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9j121
Host
Mouse
Species Reactivity
Human
Specificity
Recognizes human Decorin in direct ELISAs.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as lyophilized tissue culture supernatant in PBS, pH 7.2, 5% trehalose. Reconstitution: sterile PBS using 1ml of PBSfor a final concentration of 0.5mg/ml.
Immunogen
Sf 21-derived rhDecorin
Hybridoma
Fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, Sf 21-derived, recombinant human Decorin (rhDecorin; aa 17-359; Accession # Q5R1V9).
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 24 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-DCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DCN antibody
Decorin is a small secreted leucine rich proteoglycan that binds to fibronectin, TGF- and type I and type II collagen. Decorin has been implicated in the assembly of the extracellular matrix and the inhibition of tumor progression.
Applications Tested/Suitable for anti-DCN antibody
ELISA (EL/EIA)
Application Notes for anti-DCN antibody
Suitable for use in ELISA.
Dilution: ELISA: Used as a capture reagent in a human Decorin sandwich immunoassay in combination with biotinylated, human Decorin detection antibody and recombinant human Decorin as the
standard. The suggested coating concentration range is 2-8ug/ml and should be titrated to determine the optimal concentration.
NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,747 Da[Similar Products]
NCBI Official Full Name
decorin
NCBI Official Synonym Full Names
decorin
NCBI Official Symbol
NCBI Official Synonym Symbols
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
  [Similar Products]
NCBI Protein Information
decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II
UniProt Protein Name
Decorin
UniProt Synonym Protein Names
Bone proteoglycan II; PG-S2; PG40
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
SLRR1B  [Similar Products]
UniProt Entry Name
PGS2_HUMAN
NCBI Summary for DCN
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq]
UniProt Comments for DCN
DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; extracellular space; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; wound healing; glycosaminoglycan metabolic process; pathogenesis; response to lipopolysaccharide; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; chondroitin sulfate catabolic process; carbohydrate metabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; placenta development; aging

Disease: Corneal Dystrophy, Congenital Stromal
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-DCN antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >75 publications with DCN and TGFB1
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