Mouse Anti-FKBP6 Monoclonal Antibody – Cat# MBS200259

The cell lysates of MCF7 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human FKBP6 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

FKBP6 Antibody – Mouse Monoclonal

Name: FKBP6 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS200259
Price: 285 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200259

FKBP6 (FK506 binding protein 6) is a 327 amino acid protein. FKBP6 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP6 is essential for homologous… More details

$285 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FKBP6, Monoclonal Antibody

Full Product Name

FKBP6 antibody

Product Gene Name

anti-FKBP6 antibody

Product Synonym Names

FK506 binding protein 6 36kDa; FKBP36; PPIase FKBP6; FK506 binding protein 6; 36kDa 36 kDa FK506 binding protein; EC 5.2.1.8; FK506 binding protein 6; FKBP 36; Immunophilin FKBP36; Peptidyl prolyl cis trans isomerase; PPIase; Rotamase.

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

AT9B7

Host

Mouse

Species Reactivity

Human

Form/Format

Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.

Purity/Purification

By protein-A affinity chromatography

Concentration

1mg/ml (lot specific)

Preparation and Storage

Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

33,553 Da

OMIM

AF038847 mRNA

3D Structure

ModBase 3D Structure for O75344

Antigen Species

Human

Immunogen

Recombinant human FKBP6 (1-327aa) purified from E. coli

Clone Note

Anti-human FKBP6 mAb, clone AT9B7, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human FKBP6 protein.

Product Categories/Family for anti-FKBP6 antibody

Immunology

Applications Tested/Suitable for anti-FKBP6 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-FKBP6 antibody

Recommended starting dilution is 1:1000.

Product References and Citations for anti-FKBP6 antibody

Meng. X., et al. (1998) Genomics 52: 130-137; Crackower. M.A., et al. (2003) Science 300: 1291-1295; Metcalfe. K., et al. (2005) Clin Dysmorphol 14: 61-65;

Other Notes

Small volumes of anti-FKBP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP6 purchase

MBS200259 is an antibody targeting FKBP6. Also known as FKBP6 antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP6. It may not necessarily be applicable to this product.

NCBI GI #

146229346

NCBI GeneID

8468

NCBI Accession #

NP_003593

UniProt Primary Accession #

O75344

UniProt Secondary Accession #

Q7Z4T4; Q9UDS0; B4DXT7; G3V0I2

UniProt Related Accession #

O75344

GenBank Nucleotide #

NM_003602.4

NCBI Official Full Name

inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform a

NCBI Official Synonym Full Names

FK506 binding protein 6

NCBI Official Symbol

FKBP6

NCBI Official Synonym Symbols

FKBP36

UniProt Protein Name

Inactive peptidyl-prolyl cis-trans isomerase FKBP6

UniProt Synonym Protein Names

36 kDa FK506-binding protein; 36 kDa FKBP; FKBP-36; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36

Protein Family

FK506-binding protein

UniProt Gene Name

FKBP6

UniProt Synonym Gene Names

FKBP36; Inactive PPIase FKBP6; 36 kDa FKBP; FKBP-36; FKBP-6

NCBI Protein Information

inactive peptidyl-prolyl cis-trans isomerase FKBP6

NCBI Summary for FKBP6

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for FKBP6

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes ().

Research Articles on FKBP6

1. Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FKBP6 antibody

Reference Product	PubMed Publications
SYCP3 antibody	>2 publications with FKBP6 and SYCP3
PIWIL2 antibody	>1 publications with FKBP6 and PIWIL2
SYCP1 antibody	>1 publications with FKBP6 and SYCP1

Pathways associated with anti-FKBP6 antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Gene Silencing By RNA Pathway antibodies	Gene Silencing By RNA Pathway Diagram
Meiosis Pathway antibodies	Meiosis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
PIWI-interacting RNA (piRNA) Biogenesis Pathway antibodies	PIWI-interacting RNA (piRNA) Biogenesis Pathway Diagram

Diseases associated with anti-FKBP6 antibody

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>13 publications with FKBP6 and Infertility, Male
Congenital Abnormalities Antibodies	>10 publications with FKBP6 and Congenital Abnormalities
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies	>10 publications with FKBP6 and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Cardiovascular Diseases Antibodies	>9 publications with FKBP6 and Cardiovascular Diseases
Heart Diseases Antibodies	>9 publications with FKBP6 and Heart Diseases
Oligospermia Antibodies	>2 publications with FKBP6 and Oligospermia
Uterine Cervical Neoplasms Antibodies	>2 publications with FKBP6 and Uterine Cervical Neoplasms
Infertility, Female Antibodies	>2 publications with FKBP6 and Infertility, Female
Urogenital Abnormalities Antibodies	>1 publications with FKBP6 and Urogenital Abnormalities
Neoplasms, Experimental Antibodies	>1 publications with FKBP6 and Neoplasms, Experimental

Organs/Tissues associated with anti-FKBP6 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>12 publications with FKBP6 and Testis
Brain Antibodies	>2 publications with FKBP6 and Brain
Blood Antibodies	>1 publications with FKBP6 and Blood
Ovary Antibodies	>1 publications with FKBP6 and Ovary
Lung Antibodies	>1 publications with FKBP6 and Lung