Mouse Anti-IGF2BP3 Monoclonal Antibody – Cat# MBS9602548

Figure 1: Western blot analysis using IGF2BP3 mouse mAb against Jurkat (1), K562 (2) and NTERA-2 (3) cell lysate.

IGF2BP3 Antibody – Mouse Monoclonal

Name: IGF2BP3 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9602548
Price: 325 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9602548

Function: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IGF2BP3, Monoclonal Antibody

Full Product Name

IGF2BP3 Antibody

Product Gene Name

anti-IGF2BP3 antibody

Product Synonym Names

Cancer/testis antigen 98; CT98; DKFZp686F1078; hKOC; IF2B3_HUMAN; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA binding protein 3; IGF2 mRNA-binding protein 3; IGF2BP3; IMP 3; IMP-3; Insulin like growth factor 2 mRNA binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; KOC 1; KOC1; VICKZ 3; VICKZ family member 3; VICKZ3

Clonality

Monoclonal

Isotype

IgG1

Host

Mouse

Species Reactivity

Human

Form/Format

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity-Chromatography

Concentration

1mg/ml (lot specific)

Specificity

IGF2BP3 antibody detects endogenous levels of total IGF2BP3

Preparation and Storage

Store at -20 degree C. Stable for 12 months from date of receipt.

Molecular Weight

Observed: 69 kDa
Predicted: 64 kDa

3D Structure

ModBase 3D Structure for O00425

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Immunogen

Purified recombinant fragment of human IGF2BP3 expressed in E. Coli

Subcellular Location

Nucleus. Cytoplasm. Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.

Tissue Specificity

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-IGF2BP3 antibody

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-IGF2BP3 antibody

ELISA: 1:10000
WB: 1:500-1:2000
IHC: 1:200-1:1000

Other Notes

Small volumes of anti-IGF2BP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGF2BP3 purchase

MBS9602548 is an antibody targeting IGF2BP3. Also known as IGF2BP3 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IGF2BP3. It may not necessarily be applicable to this product.

NCBI GI #

30795212

NCBI GeneID

10643

NCBI Accession #

NP_006538.2

UniProt Primary Accession #

O00425

UniProt Secondary Accession #

Q63HM0; Q6MZZ2; Q86VB1; A0A4Z5

UniProt Related Accession #

O00425

GenBank Nucleotide #

NM_006547.2

NCBI Official Full Name

insulin-like growth factor 2 mRNA-binding protein 3

NCBI Official Synonym Full Names

insulin like growth factor 2 mRNA binding protein 3

NCBI Official Symbol

IGF2BP3

NCBI Official Synonym Symbols

KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3

UniProt Protein Name

Insulin-like growth factor 2 mRNA-binding protein 3

UniProt Synonym Protein Names

IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3

Protein Family

Insulin-like growth factor 2 mRNA-binding protein

UniProt Gene Name

IGF2BP3

UniProt Synonym Gene Names

IMP3; KOC1; VICKZ3; IGF2 mRNA-binding protein 3; IMP-3; hKOC

NCBI Protein Information

insulin-like growth factor 2 mRNA-binding protein 3

NCBI Summary for IGF2BP3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

UniProt Comments for IGF2BP3

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.

Research Articles on IGF2BP3

1. Data show that insulin-like growth factor-II mRNA-binding protein 2 and 3 (IMP2/3)-miR-200a-progesterone receptor axis represents a double-negative feedback loop and serves as a new potential therapeutic target for the treatment of Triple-negative breast cancer (TNBC).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IGF2BP3 antibody

Products by Pathway	Pathway Diagram
Binding Of RNA By Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Pathway antibodies	Binding Of RNA By Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram

Diseases associated with anti-IGF2BP3 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>13 publications with IGF2BP3 and Neoplasms
Carcinoma Antibodies	>10 publications with IGF2BP3 and Carcinoma
Pancreatic Neoplasms Antibodies	>2 publications with IGF2BP3 and Pancreatic Neoplasms
Liver Diseases Antibodies	>2 publications with IGF2BP3 and Liver Diseases
Ovarian Neoplasms Antibodies	>2 publications with IGF2BP3 and Ovarian Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with IGF2BP3 and Neoplasms, Experimental
Recurrence Antibodies	>1 publications with IGF2BP3 and Recurrence
Liver Neoplasms Antibodies	>1 publications with IGF2BP3 and Liver Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with IGF2BP3 and Neoplasm Metastasis
Abnormalities, Multiple Antibodies	>1 publications with IGF2BP3 and Abnormalities, Multiple

Organs/Tissues associated with anti-IGF2BP3 antibody

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>2 publications with IGF2BP3 and Pancreas
Blood Antibodies	>2 publications with IGF2BP3 and Blood
Liver Antibodies	>2 publications with IGF2BP3 and Liver
Brain Antibodies	>2 publications with IGF2BP3 and Brain
Placenta Antibodies	>2 publications with IGF2BP3 and Placenta
Embryonic Tissue Antibodies	>2 publications with IGF2BP3 and Embryonic Tissue
Lung Antibodies	>1 publications with IGF2BP3 and Lung
Uterus Antibodies	>1 publications with IGF2BP3 and Uterus
Lymph Antibodies	>1 publications with IGF2BP3 and Lymph
Bone Marrow Antibodies	>1 publications with IGF2BP3 and Bone Marrow