PP5 Antibody – Mouse Monoclonal

This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

PPP5C: a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis.

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus; perikaryon; plasma membrane; protein complex

Molecular Function: ADP binding; ATP binding; G-protein alpha-subunit binding; heat shock protein binding; identical protein binding; lipid binding; metal ion binding; microtubule binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; RNA binding; signal transducer activity

Biological Process: activation of MAPKK activity; axon guidance; DNA repair; double-strand break repair; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; histone dephosphorylation; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; mitosis; negative regulation of protein amino acid phosphorylation; nerve growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid dephosphorylation; protein heterooligomerization; Ras protein signal transduction; response to lead ion; response to morphine; small GTPase mediated signal transduction; transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway