Mouse Anti-PSMC4 Monoclonal Antibody – Cat# MBS6188456

PSMC4 Antibody – Mouse Monoclonal

Name: PSMC4 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6188456
Price: 960 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6188456

MBS6188456 is an antibody targeting PSMC4. Also known as PSMC4 (26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, 26S Proteasome AAA-ATPase Subunit RPT3, MB67-interacting Protein 1, MIP224, Tat-binding Protein 7, TBP-7, MIP224, TBP7) (Azide… More details

$960 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSMC4, Monoclonal Antibody

Full Product Name

PSMC4 (26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, 26S Proteasome AAA-ATPase Subunit RPT3, MB67-interacting Protein 1, MIP224, Tat-binding Protein 7, TBP-7, MIP224, TBP7) (Azide Free) (MaxLight 405)

Product Gene Name

anti-PSMC4 antibody

Clonality

Monoclonal

Isotype

IgG2a,k

Clone Number

11C606

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

Purity/Purification

Purified by Affinity Chromatography

Specificity

Recognizes human PSMC4.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

47366

Immunogen

Full length recombinant protein corresponding to aa1-419 from human PSMC4 with GST tag. MW of GST alone is 26kD.

Conjugate

MaxLight405

Product Categories/Family for anti-PSMC4 antibody

Antibodies; Proteasomes

Applications Tested/Suitable for anti-PSMC4 antibody

FLISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

Application Notes for anti-PSMC4 antibody

FLISA: 1ug/ml-3ng/ml
IHC-P: 1.5ug/ml
WB: 1:500-1:1000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PSMC4 antibody

1. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732. 2. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Kaneko T, et al. Cell, 2009 May 29. PMID 19490896. 3. Chaperone-mediated pathway of proteasome regulatory particle assembly. Roelofs J, et al. Nature, 2009 Jun 11. PMID 19412159. 4. A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients. Wahl C, et al. J Neural Transm, 2008 Aug. PMID 18446261. 5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

Other Notes

Small volumes of anti-PSMC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMC4. It may not necessarily be applicable to this product.

NCBI GI #

12653151

NCBI GeneID

5704

NCBI Accession #

AAH00343

UniProt Related Accession #

P43686

NCBI Official Full Name

Proteasome (prosome, macropain) 26S subunit, ATPase, 4

NCBI Official Synonym Full Names

proteasome 26S subunit, ATPase 4

NCBI Official Symbol

PSMC4

NCBI Official Synonym Symbols

S6; RPT3; TBP7; TBP-7; MIP224

Protein Family

26S protease regulatory

NCBI Protein Information

26S proteasome regulatory subunit 6B

NCBI Summary for PSMC4

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Research Articles on PSMC4

1. This study demonstrated that particular distribution for HSC70 and PSMC4 in the cytoplasm and accumulation within Lewy body in the dopaminergic neurons of the substantia nigra in Parkinson patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.