Rabbit Anti-RRM2 Monoclonal Antibody – Cat# MBS9467274

Western blot detection of RRM2 in K562,Hela cell lysates using RRM2 Rabbit mAb(1:1000 diluted).Predicted band size:45kDa.Observed band size:45kDa.

RRM2 Antibody – Rabbit Monoclonal

Name: RRM2 Antibody; Monoclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9467274
Price: 270 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9467274

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.MiscellaneousTwo distinct regulatory sites have been defined: the specificity site, which… More details

$270 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RRM2, Monoclonal Antibody

Full Product Name

RRM2 Rabbit mAb

Product Gene Name

anti-RRM2 antibody

Product Synonym Names

R2; RR2; RR2M

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone Number

S09-4G8

Host

Recombinant Rabbit

Species Reactivity

Human

Form/Format

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purity/Purification

Affinity Purified

Concentration

0.3mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.

Molecular Weight

51,093 Da

OMIM

180390

3D Structure

ModBase 3D Structure for P31350

Immunogen

Recombinant protein of human RRM2

Conjugation

Unconjugated

Modification

Unmodification

Product Categories/Family for anti-RRM2 antibody

Primary Antibody

Applications Tested/Suitable for anti-RRM2 antibody

Western Blot (WB)

Application Notes for anti-RRM2 antibody

WB: 1/1000

Other Notes

Small volumes of anti-RRM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RRM2 purchase

MBS9467274 is an antibody targeting RRM2. Also known as RRM2 Rabbit mAb. Reactive in Human. Host: Recombinant Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RRM2. It may not necessarily be applicable to this product.

NCBI GI #

4557845

NCBI GeneID

6241

NCBI Accession #

NP_001025.1

UniProt Primary Accession #

P31350

UniProt Secondary Accession #

Q5WRU7; B2R9B5; J3KP43

UniProt Related Accession #

P31350

GenBank Nucleotide #

NM_001034.3

NCBI Official Full Name

ribonucleoside-diphosphate reductase subunit M2 isoform 2

NCBI Official Synonym Full Names

ribonucleotide reductase M2

NCBI Official Symbol

RRM2

NCBI Official Synonym Symbols

R2; RR2; RR2M

UniProt Protein Name

Ribonucleoside-diphosphate reductase subunit M2

UniProt Synonym Protein Names

Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit

Protein Family

Ribonucleoside-diphosphate reductase

UniProt Gene Name

RRM2

UniProt Synonym Gene Names

RR2

UniProt Entry Name

RIR2_HUMAN

NCBI Protein Information

ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit

NCBI Summary for RRM2

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

UniProt Comments for RRM2

RRM2: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family.

Protein type: Nucleotide Metabolism - purine; Oxidoreductase; EC 1.17.4.1; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 2p25-p24

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; metal ion binding; ribonucleoside-diphosphate reductase activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; deoxyribonucleoside diphosphate metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; deoxyribonucleotide biosynthetic process; protein heterotetramerization; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle

Research Articles on RRM2

1. RRM2 is a new molecular marker for the diagnosis and clinical outcomes of cervical cancer. It is involved in cervical carcinogenesis and predicts poor survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RRM2 antibody

Reference Product	PubMed Publications
RRM1 antibody	>119 publications with RRM2 and RRM1
E2F1 antibody	>4 publications with RRM2 and E2F1
CDK1 antibody	>4 publications with RRM2 and CDK1
CCNA2 antibody	>2 publications with RRM2 and CCNA2
PCNA antibody	>2 publications with RRM2 and PCNA
TYMS antibody	>2 publications with RRM2 and TYMS
CDC6 antibody	>1 publications with RRM2 and CDC6

Pathways associated with anti-RRM2 antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
E2F Mediated Regulation Of DNA Replication Pathway antibodies	E2F Mediated Regulation Of DNA Replication Pathway Diagram
E2F Transcription Factor Network Pathway antibodies	E2F Transcription Factor Network Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram
G1/S Transition Pathway antibodies	G1/S Transition Pathway Diagram
G1/S-Specific Transcription Pathway antibodies	G1/S-Specific Transcription Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram

Diseases associated with anti-RRM2 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>32 publications with RRM2 and Adenocarcinoma
Breast Neoplasms Antibodies	>16 publications with RRM2 and Breast Neoplasms
Lung Neoplasms Antibodies	>15 publications with RRM2 and Lung Neoplasms
Neoplasms, Experimental Antibodies	>13 publications with RRM2 and Neoplasms, Experimental
Nervous System Diseases Antibodies	>10 publications with RRM2 and Nervous System Diseases
Colorectal Neoplasms Antibodies	>9 publications with RRM2 and Colorectal Neoplasms
Liver Neoplasms Antibodies	>5 publications with RRM2 and Liver Neoplasms
Brain Diseases Antibodies	>5 publications with RRM2 and Brain Diseases
Ovarian Neoplasms Antibodies	>5 publications with RRM2 and Ovarian Neoplasms
Liver Diseases Antibodies	>5 publications with RRM2 and Liver Diseases

Organs/Tissues associated with anti-RRM2 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>20 publications with RRM2 and Lung
Blood Antibodies	>13 publications with RRM2 and Blood
Brain Antibodies	>10 publications with RRM2 and Brain
Liver Antibodies	>8 publications with RRM2 and Liver
Bone Antibodies	>7 publications with RRM2 and Bone
Lymph Node Antibodies	>6 publications with RRM2 and Lymph Node
Prostate Antibodies	>6 publications with RRM2 and Prostate
Lymph Antibodies	>6 publications with RRM2 and Lymph
Muscle Antibodies	>5 publications with RRM2 and Muscle
Nerve Antibodies	>5 publications with RRM2 and Nerve