SPAG6 Antibody – Mouse Monoclonal

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq]

SPAG6: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 10p12.2

Cellular Component: microtubule cytoskeleton; microtubule; axoneme; nucleus

Biological Process: cell projection organization and biogenesis; spermatid development