Mouse Anti-TLE4 Monoclonal Antibody – Cat# MBS6009118

TLE4 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TLE4 antibody detected the TLE4 protein (arrow).

TLE4 Antibody – Mouse Monoclonal

Name: TLE4 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6009118
Price: 820 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6009118

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by… More details

$820 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TLE4, Monoclonal Antibody

Full Product Name

TLE4, ID (TLE4, KIAA1261, Transducin-like enhancer protein 4)

Product Gene Name

anti-TLE4 antibody

Product Synonym Names

Anti -TLE4, ID (TLE4, KIAA1261, Transducin-like enhancer protein 4)

Clonality

Monoclonal

Isotype

IgM

Clone Number

384CT24.1.3.4

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid, crude ascites with 0.09% sodium azide.

Purity/Purification

Ascites
Ascites

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

83,755 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (82186878..82341658). Location: 9q21.31

OMIM

605132

3D Structure

ModBase 3D Structure for Q04727

Immunogen

TLE4 Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from the center region of human TLE4.

Product Categories/Family for anti-TLE4 antibody

Antibodies; Abs to Wnt Proteins

Applications Tested/Suitable for anti-TLE4 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TLE4 antibody

Suitable for use in Western Blot, ELISA.
Dilution: ELISA: 1:1,000
Western Blot: 1:100~3200

Other Notes

Small volumes of anti-TLE4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLE4 purchase

MBS6009118 is an antibody targeting TLE4. Also known as TLE4, ID (TLE4, KIAA1261, Transducin-like enhancer protein 4). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TLE4. It may not necessarily be applicable to this product.

NCBI GI #

544224628

NCBI GeneID

7091

NCBI Accession #

NP_001269677.1

UniProt Primary Accession #

Q04727

UniProt Secondary Accession #

Q3ZCS1; Q5T1Y2; Q6PCB3; Q9BZ07; Q9BZ08; Q9BZ09; Q9NSL3; Q9ULF9

UniProt Related Accession #

Q04727

GenBank Nucleotide #

NM_001282748.1

NCBI Official Full Name

transducin-like enhancer protein 4 isoform 1

NCBI Official Synonym Full Names

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

NCBI Official Symbol

TLE4

NCBI Official Synonym Symbols

ESG; BCE1; ESG4; GRG4; BCE-1; E(spI)

UniProt Protein Name

Transducin-like enhancer protein 4

Protein Family

Transducin-like enhancer protein

UniProt Gene Name

TLE4

UniProt Synonym Gene Names

KIAA1261

UniProt Entry Name

TLE4_HUMAN

NCBI Protein Information

transducin-like enhancer protein 4; B lymphocyte gene 1; enhancer of split groucho 4; transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

UniProt Comments for TLE4

TLE4: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. In all tissues examined, mostly in brain, and muscle. Belongs to the WD repeat Groucho/TLE family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 9q21.31

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin binding; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter

Research Articles on TLE4

1. Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TLE4 antibody

Products by Pathway	Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies	FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies	NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By NOTCH Pathway antibodies	Signaling By NOTCH Pathway Diagram
Signaling By NOTCH1 Pathway antibodies	Signaling By NOTCH1 Pathway Diagram
Signaling By NOTCH1 HD Domain Mutants In Cancer Pathway antibodies	Signaling By NOTCH1 HD Domain Mutants In Cancer Pathway Diagram
Signaling By NOTCH1 HD+PEST Domain Mutants In Cancer Pathway antibodies	Signaling By NOTCH1 HD+PEST Domain Mutants In Cancer Pathway Diagram

Diseases associated with anti-TLE4 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>12 publications with TLE4 and Neoplasms
Lung Diseases Antibodies	>2 publications with TLE4 and Lung Diseases
Respiratory Tract Diseases Antibodies	>2 publications with TLE4 and Respiratory Tract Diseases
Intestinal Neoplasms Antibodies	>2 publications with TLE4 and Intestinal Neoplasms
Carcinoma Antibodies	>2 publications with TLE4 and Carcinoma
Adenoma Antibodies	>1 publications with TLE4 and Adenoma
Disease Models, Animal Antibodies	>1 publications with TLE4 and Disease Models, Animal
Embryo Loss Antibodies	>1 publications with TLE4 and Embryo Loss
Neoplasms, Experimental Antibodies	>1 publications with TLE4 and Neoplasms, Experimental
Lymphoma Antibodies	>1 publications with TLE4 and Lymphoma

Organs/Tissues associated with anti-TLE4 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with TLE4 and Brain
Embryonic Tissue Antibodies	>7 publications with TLE4 and Embryonic Tissue
Nerve Antibodies	>4 publications with TLE4 and Nerve
Blood Antibodies	>3 publications with TLE4 and Blood
Eye Antibodies	>3 publications with TLE4 and Eye
Kidney Antibodies	>3 publications with TLE4 and Kidney
Lung Antibodies	>2 publications with TLE4 and Lung
Pancreas Antibodies	>2 publications with TLE4 and Pancreas
Bone Antibodies	>2 publications with TLE4 and Bone
Heart Antibodies	>2 publications with TLE4 and Heart