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UVRAG Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6134508

UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human… More details

$995 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UVRAG, Monoclonal Antibody
Full Product Name
UVRAG (UV Radiation Resistance-associated Gene Protein, p63, DHTX, VPS38) (AP)
Product Gene Name
Product Synonym Names
DHTX; p63; UV Radiation Resistance Associated Gene Protein
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2E8
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human UVRAG.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
35,988 Da
OMIM
602493
3D Structure
ModBase 3D Structure for Q9P2Y5
Immunogen
Partial recombinant corresponding to aa601-699 from human UVRAG (NP_003360) with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
LPSEQAGSASVQLPGEFHPVSEAELCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK
Conjugate
AP

Product Categories/Family for anti-UVRAG antibody

Applications Tested/Suitable for anti-UVRAG antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-UVRAG antibody
Applications are based on unconjugated antibody.

Testing Data of anti-UVRAG antibody

Detection limit for recombinant GST tagged UVRAG is 0.3ng/ml as a capture antibody.
Mouse Anti-UVRAG Monoclonal Antibody – Cat# MBS6134508

Other Notes

Small volumes of anti-UVRAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UVRAG purchase

MBS6134508 is an antibody targeting UVRAG. Also known as UVRAG (UV Radiation Resistance-associated Gene Protein, p63, DHTX, VPS38) (AP). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for UVRAG. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
UV radiation resistance-associated gene protein
NCBI Official Synonym Full Names
UV radiation resistance associated
NCBI Official Symbol
UVRAG
NCBI Official Synonym Symbols
p63; DHTX; VPS38
UniProt Protein Name
UV radiation resistance-associated gene protein
UniProt Synonym Protein Names
p63
UniProt Gene Name
UVRAG
UniProt Entry Name
UVRAG_HUMAN
NCBI Protein Information
UV radiation resistance-associated gene protein

NCBI Summary for UVRAG

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]
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UniProt Comments for UVRAG

UVRAG: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: protein complex; lysosome; early endosome; late endosome; cytoplasm; phagocytic vesicle

Molecular Function: protein binding; SNARE binding; SH3 domain binding

Biological Process: entry of virus into host cell; DNA repair; positive regulation of autophagy
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-UVRAG antibody

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