Rat Anti-CD11b Monoclonal Antibody – Cat# MBS2579446

Staining of C57BL/6 murine splenocytes with Fluor 700 Anti-Mouse/Human CD11b Antibody [M1/70] (filled gray histogram) or Fluor 700 Rat IgG2b, kappa Isotype Control (empty black histogram). Total viable cells were used for analysis.

CD11b Antibody – Rat Monoclonal

Name: CD11b Antibody; Monoclonal; Rat; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2579446
Price: 155 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2579446

CD11b is a 170 kD glycoprotein also known as alphaM integrin, Mac-1 alpha subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B… More details

$155 / 0.025 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD11b, Monoclonal Antibody

Full Product Name

Fluor700 Anti-Mouse/Human CD11b Antibody [M1/70]

Product Gene Name

anti-CD11b antibody

Product Synonym Names

CD11 antigen-like family member B; CD11b; CR-3 alpha chain; Integrin alpha-M; Itgam; Leukocyte adhesion receptor MO1

Clonality

Monoclonal

Isotype

Rat IgG2b, kappa

Clone Number

M1/70

Host

Rat

Species Reactivity

Human, Mouse

Form/Format

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Preparation and Storage

This product can be stored at 2-8 degree C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Matching Pairs

Antibody: CD11b (MBS2579446)
Isotype Control: IgG2b,kappa Clone #LTF-2 (MBS2579353)

Molecular Weight

115,196 Da

3D Structure

ModBase 3D Structure for P05555

Conjugation

Fluor700

Product Categories/Family for anti-CD11b antibody

Flow Cytometry Antibodies; Primary Antibodies; Flow Cytometry Antibodies

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CD11b antibody

Flow Cytometry (FC/FACS/FCM)

Other Notes

Small volumes of anti-CD11b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD11b purchase

MBS2579446 is an antibody targeting CD11b. Also known as Fluor700 Anti-Mouse/Human CD11b Antibody [M1/70]. Reactive in Human, Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD11b. It may not necessarily be applicable to this product.

NCBI GI #

124956

NCBI GeneID

16409

NCBI Accession #

P05555.2

UniProt Primary Accession #

P05555

UniProt Secondary Accession #

P11215

UniProt Related Accession #

P05555

NCBI Official Full Name

Integrin alpha-M

NCBI Official Synonym Full Names

integrin alpha M

NCBI Official Symbol

Itgam

NCBI Official Synonym Symbols

CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik

UniProt Protein Name

Integrin alpha-M

UniProt Synonym Protein Names

CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; CD_antigen: CD11b

Protein Family

Integrin

UniProt Gene Name

Itgam

UniProt Entry Name

ITAM_MOUSE

NCBI Protein Information

integrin alpha-M; Mac-1 alpha; CD11B (p170); CR-3 alpha chain; macrophage antigen alpha; complement receptor type 3; leukocyte adhesion receptor MO1; CD11 antigen-like family member B; complement component receptor 3 alpha-a; cell surface glycoprotein MAC

UniProt Comments for CD11b

ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; nucleus; integrin complex; external side of plasma membrane

Molecular Function: heparin binding; heparan sulfate proteoglycan binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; cell-cell adhesion; leukocyte adhesion; microglia development; cellular extravasation; activated T cell proliferation; cell adhesion; leukocyte migration during inflammatory response

Research Articles on CD11b

1. Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD11b antibody

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Organs/Tissues associated with anti-CD11b antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4438 publications with CD11b and Blood
Bone Marrow Antibodies	>767 publications with CD11b and Bone Marrow
Brain Antibodies	>612 publications with CD11b and Brain
Lung Antibodies	>526 publications with CD11b and Lung
Spleen Antibodies	>505 publications with CD11b and Spleen
Skin Antibodies	>241 publications with CD11b and Skin
Heart Antibodies	>202 publications with CD11b and Heart
Spinal Cord Antibodies	>162 publications with CD11b and Spinal Cord
Intestine Antibodies	>154 publications with CD11b and Intestine
Eye Antibodies	>146 publications with CD11b and Eye