RIT Antibody – Mouse Monoclonal

Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation

By similarity.

Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP

By similarity.

Subunit structure: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state

By similarity. Interacts with RGL3. Ref.4

Subcellular location: Cell membrane.

Tissue specificity: Expressed in many tissues.

Miscellaneous: Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation

By similarity.Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are very much 10-fold faster than those of most Ras subfamily members

By similarity.

Sequence similarities: Belongs to the small GTPase superfamily. Ras family.