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CD22 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2558158

The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD22, Monoclonal Antibody
Full Product Name
Anti-Mouse CD22 Monoclonal Antibody (PE Conjugated) [Cy34.1]
Product Gene Name
anti-CD22 antibody
Product Synonym Gene Name
Mouse CD22
Product Synonym Names
B-cell receptor CD22; Cd22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22; Lyb-8; Siglec2
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
Cy34.1
Host
Mouse
Species Reactivity
Mouse
Form/Format
PBS with 0.05% Proclin300, 1% BSA
Concentration
0.5 mg/mL (lot specific)
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
3D Structure
ModBase 3D Structure for P35329
Conjugation
PE
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD22 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD22 antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Flow Cytometry (FC/FACS) of anti-CD22 antibody

C57BL/6 murine splenocytes are stained with Anti-Mouse CD22 Monoclonal Antibody(PE Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.
Mouse Anti-CD22 Monoclonal Antibody – Cat# MBS2558158

Other Notes

Small volumes of anti-CD22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD22 purchase

MBS2558158 is an antibody targeting CD22. Also known as Anti-Mouse CD22 Monoclonal Antibody (PE Conjugated) [Cy34.1]. Reactive in Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD22. It may not necessarily be applicable to this product.

NCBI GI #
461664
NCBI GeneID
12483
NCBI Accession #
P35329.1
UniProt Primary Accession #
P35329
UniProt Related Accession #
P35329
NCBI Official Full Name
B-cell receptor CD22
NCBI Official Synonym Full Names
CD22 antigen
NCBI Official Symbol
Cd22
NCBI Official Synonym Symbols
Lyb8; Lyb-8; A530093D23
UniProt Protein Name
B-cell receptor CD22
UniProt Synonym Protein Names
B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22
Protein Family
B-cell receptor
UniProt Gene Name
Cd22
UniProt Synonym Gene Names
Lyb-8; Siglec2; BL-CAM; Siglec-2
UniProt Entry Name
CD22_MOUSE
NCBI Protein Information
B-cell receptor CD22

UniProt Comments for CD22

CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity; carbohydrate binding

Biological Process: cell surface receptor linked signal transduction; cell adhesion
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Research Articles on CD22

1. Synthetic sialosides that bind to CD22 with high-affinity modulate B cell activation through endogenous ligand-dependent and independent pathways, and carry an adjuvant activity without inducing inflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD22 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with anti-CD22 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >950 publications with CD22 and Immune System Diseases
 Neoplasms, Experimental Antibodies  >105 publications with CD22 and Neoplasms, Experimental
 Inflammation Antibodies  >56 publications with CD22 and Inflammation
 Necrosis Antibodies  >51 publications with CD22 and Necrosis
 Respiratory Tract Diseases Antibodies  >45 publications with CD22 and Respiratory Tract Diseases
 Cell Transformation, Neoplastic Antibodies  >23 publications with CD22 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >21 publications with CD22 and Kidney Diseases
 Liver Diseases Antibodies  >19 publications with CD22 and Liver Diseases
 Lung Diseases Antibodies  >17 publications with CD22 and Lung Diseases
 Lung Neoplasms Antibodies  >15 publications with CD22 and Lung Neoplasms

Organs/Tissues associated with anti-CD22 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1042 publications with CD22 and Blood
 Bone Marrow Antibodies  >286 publications with CD22 and Bone Marrow
 Spleen Antibodies  >121 publications with CD22 and Spleen
 Lymph Node Antibodies  >110 publications with CD22 and Lymph Node
 Skin Antibodies  >47 publications with CD22 and Skin
 Embryonic Tissue Antibodies  >13 publications with CD22 and Embryonic Tissue
 Nasopharynx Antibodies  >5 publications with CD22 and Nasopharynx
 Inner Ear Antibodies  >1 publications with CD22 and Inner Ear
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