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ENaC beta Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS808301

The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1).… More details

$575 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
ENaC beta, Monoclonal Antibody
Full Product Name
ENaC beta Antibody, Clone 7B8: PerCP
Product Gene Name
anti-ENaC beta antibody
Product Synonym Names
Mouse Anti-Rat ENaC beta Monoclonal IgG1; SCNN1B Antibody; Amiloride sensitive sodium channel subunit beta Antibody; Amiloride-sensitive sodium channel beta-subunit Antibody; Beta ENaC Antibody; Beta NaCH Antibody; ENaC beta Antibody; ENaCB Antibody; Epithelial Na(+) channel subunit beta Antibody; Epithelial Na+ channel beta subunit Antibody; Epithelial Na+ channel subunit beta Antibody; Epithelial sodium channel beta 2 subunit Antibody; Epithelial sodium channel beta 3 subunit Antibody; Nonvoltage gated sodium channel 1 beta subunit Antibody; Nonvoltage gated sodium channel 1 subunit beta Antibody; Nonvoltage-gated sodium channel 1 beta subunit Antibody; SCNEB Antibody; SCNN 1B Antibody; Sodium channel nonvoltage gated 1 beta (Liddle syndrome) Antibody; Sodium channel nonvoltage gated 1 beta Antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7B8
Host
Mouse
Species Reactivity
Mouse
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Detects ~87kDa.
Preparation and Storage
Store at -20 degree C.
Matching Pairs
Unconjugated Antibody: ENaC beta Clone #7B8 (MBS808286)
PerCP Conjugated Antibody: ENaC beta Clone #7B8 (MBS808301)
Matching Pairs
Unconjugated Antibody: N/A (MBS808301)
PerCP Conjugated Antibody: ENaC beta Clone #7B8 (MBS808301)
Molecular Weight
71,995 Da
3D Structure
ModBase 3D Structure for P37090
Target
ENaC beta
Immunogen
Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)
Immunogen Species
Rat
Cellular Localization
Apical Cell Membrane
Conjugate
PerCP
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide

Product Categories/Family for anti-ENaC beta antibody

Antibodies; Neuroscience; Ion Channels; Sodium Channels; Epithelial Sodium Channels (ENaC)
Applications Tested/Suitable for anti-ENaC beta antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ENaC beta antibody
WB: 1:1000
IHC: 1:150

Immunohistochemistry (IHC) of anti-ENaC beta antibody

Immunohistochemistry analysis using Mouse Anti-ENaC beta Monoclonal Antibody, Clone 7B8. Tissue: Kidney (cortex). Species: Mouse. Primary Antibody: Mouse Anti-ENaC beta Monoclonal Antibody at 1:150. Localization: Collecting duct principal cells. Magnification: 60X.
Mouse Anti-ENaC beta Monoclonal Antibody – Cat# MBS808301

Western Blot (WB) of anti-ENaC beta antibody

Western Blot analysis of Mouse Whole kidney homogenates showing detection of ~87kDa ENaC beta protein using Mouse Anti-ENaC beta Monoclonal Antibody, Clone 7B8. Lane 1: Molecular Weight Ladder (MW). Lane 2: Low-salt diet. Lane 3: Normal-salt diet. Load: 20 ug. Primary Antibody: Mouse Anti-ENaC beta Monoclonal Antibody at 1:1000. Predicted/Observed Size: ~87kDa.
Mouse Anti-ENaC beta Monoclonal Antibody, Western Blot (WB) – Cat# MBS808301

Product References and Citations for anti-ENaC beta antibody

1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216(2):453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128.

Other Notes

Small volumes of anti-ENaC beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ENaC beta purchase

MBS808301 is an antibody targeting ENaC beta. Also known as ENaC beta Antibody, Clone 7B8: PerCP. Reactive in Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ENaC beta. It may not necessarily be applicable to this product.

NCBI GI #
25742736
NCBI GeneID
24767
NCBI Accession #
NP_036780
UniProt Primary Accession #
P37090
UniProt Secondary Accession #
O09183
UniProt Related Accession #
P37090
GenBank Nucleotide #
NM_012648.1
NCBI Official Full Name
amiloride-sensitive sodium channel subunit beta
NCBI Official Synonym Full Names
sodium channel epithelial 1 beta subunit
NCBI Official Symbol
Scnn1b
NCBI Official Synonym Symbols
RNENACB
UniProt Protein Name
Amiloride-sensitive sodium channel subunit beta
UniProt Synonym Protein Names
Beta-NaCH; Epithelial Na(+) channel subunit beta; Beta-ENaC; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB
UniProt Gene Name
Scnn1b
UniProt Synonym Gene Names
Beta-ENaC
NCBI Protein Information
amiloride-sensitive sodium channel subunit beta

NCBI Summary for ENaC beta

acts as an epithelial sodium ion channel; regulates salt and fluid transport in the kidney [RGD, Feb 2006]

UniProt Comments for ENaC beta

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
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Research Articles on ENaC beta

1. deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ENaC beta antibody

 Reference Product  PubMed Publications
 Scnn1g antibody  >83 publications with ENaC beta and Scnn1g
 Scnn1a antibody  >67 publications with ENaC beta and Scnn1a
 Nedd4l antibody  >10 publications with ENaC beta and Nedd4l

Pathways associated with anti-ENaC beta antibody

 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Interactions Between CFTR And Other Ion Channels Pathway antibodies  Interactions Between CFTR And Other Ion Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ENaC beta antibody

 Disease Name  Pubmed Publications
 Bronchiectasis With Or Without Elevated Sweat Chloride 1 Antibodies  >84 publications with ENaC beta and Bronchiectasis With Or Without Elevated Sweat Chloride 1
 Hypertension Antibodies  >73 publications with ENaC beta and Hypertension
 Cardiovascular Diseases Antibodies  >54 publications with ENaC beta and Cardiovascular Diseases
 Liddle Syndrome Antibodies  >42 publications with ENaC beta and Liddle Syndrome
 Lung Diseases Antibodies  >42 publications with ENaC beta and Lung Diseases
 Kidney Diseases Antibodies  >41 publications with ENaC beta and Kidney Diseases
 Cystic Fibrosis Antibodies  >38 publications with ENaC beta and Cystic Fibrosis
 Fibrosis Antibodies  >38 publications with ENaC beta and Fibrosis
 Pseudohypoaldosteronism Antibodies  >26 publications with ENaC beta and Pseudohypoaldosteronism
 Disease Models, Animal Antibodies  >23 publications with ENaC beta and Disease Models, Animal

Organs/Tissues associated with anti-ENaC beta antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >47 publications with ENaC beta and Kidney
 Placenta Antibodies  >5 publications with ENaC beta and Placenta
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