Rat Anti-JAM-A Monoclonal Antibody – Cat# MBS6245724

Staining of bEnd.3 cells with 029519 (:1000) with 1ug of rat IgG2b isotype control. Highest MFI (green) of two sample peaks (histogram) indicates JAM-A positive bEnd.3 cells.

JAM-A Antibody – Rat Monoclonal

Name: JAM-A Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6245724
Price: 1335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6245724

MBS6245724 is an antibody targeting JAM-A. Also known as JAM-A (Junctional Adhesion Molecule A, Junctional Adhesion Molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1) (MaxLight 490). Reactive in Mouse. Host: Rat. More details

$1335 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JAM-A, Monoclonal Antibody

Full Product Name

JAM-A (Junctional Adhesion Molecule A, Junctional Adhesion Molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1) (MaxLight 490)

Product Gene Name

anti-JAM-A antibody

Clonality

Monoclonal

Isotype

IgG2b,k

Clone Number

13A203

Host

Rat

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

Purity/Purification

Purified by Protein G Affinity Chromatography

Specificity

Recognizes mouse JAM-A.

Preparation and Storage

Store at 4 degree C. Do Not Freeze.

Molecular Weight

3D Structure

ModBase 3D Structure for O88792

Immunogen

H5V murine heart capillary endothelial cells.

Conjugate

MaxLight490

Product Categories/Family for anti-JAM-A antibody

Antibodies; Connexin; Junction Proteins

Applications Tested/Suitable for anti-JAM-A antibody

Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Product References and Citations for anti-JAM-A antibody

1. Nava, P., et al. (2011). EMBO Rep. 12(4):314-320. 2. Laukoetter, M.G., et al. (2007). J Exp Med. 204(13):3067-3076. 3. Parris, J.J., et al. (2005). Dev Dyn. 233(4): 1517-1524. 4. Ostermann, G., et al. (2005). Arterioscler Thromb Vasc Biol. 25(4):729-735. 5. Martin-Padura, I., et al. (1998). J Cell Biol. 142(1):117-127. 6. Scheiermann, C., et al. (2007). Science. 318(5855): 1472-1475.

Other Notes

Small volumes of anti-JAM-A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for JAM-A. It may not necessarily be applicable to this product.

NCBI GI #

27734847

NCBI GeneID

16456

NCBI Accession #

NP_766235

UniProt Primary Accession #

O88792

UniProt Related Accession #

O88792

GenBank Nucleotide #

NP_766235.1

NCBI Official Full Name

junctional adhesion molecule A

NCBI Official Synonym Full Names

F11 receptor

NCBI Official Symbol

F11r

NCBI Official Synonym Symbols

JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24

UniProt Protein Name

Junctional adhesion molecule A

UniProt Synonym Protein Names

Junctional adhesion molecule 1; JAM-1; CD_antigen: CD321

Protein Family

Junctional adhesion molecule

UniProt Gene Name

F11r

UniProt Synonym Gene Names

Jam1; Jcam; Jcam1; JAM-A; JAM-1

UniProt Entry Name

JAM1_MOUSE

NCBI Protein Information

junctional adhesion molecule A

UniProt Comments for JAM-A

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Cell adhesion

Cellular Component: microtubule cytoskeleton; tight junction; membrane; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; cell junction

Molecular Function: protein binding; PDZ domain binding

Biological Process: viral reproduction; epithelial cell differentiation; actomyosin structure organization and biogenesis; cell adhesion; positive regulation of blood pressure; intestinal absorption

Research Articles on JAM-A

1. Mice with total loss of JAM-A or mice with intestinal epithelial selective loss of JAM-A had increased colonic permeability and reduced polymorphonuclear neutrophils (PMN) migration into the colonic lumen. These findings highlight a potentially novel role for JAM-A in regulating PMN transepithelial migration in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JAM-A antibody

Reference Product	PubMed Publications
Tjp1 antibody	>24 publications with JAM-A and Tjp1
Itgb2 antibody	>2 publications with JAM-A and Itgb2
Mllt4 antibody	>2 publications with JAM-A and Mllt4
Pard6a antibody	>1 publications with JAM-A and Pard6a
Mpdz antibody	>1 publications with JAM-A and Mpdz

Pathways associated with anti-JAM-A antibody

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Integrin Cell Surface Interactions Pathway antibodies	Integrin Cell Surface Interactions Pathway Diagram

Diseases associated with anti-JAM-A antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>28 publications with JAM-A and Inflammation
Necrosis Antibodies	>13 publications with JAM-A and Necrosis
Breast Neoplasms Antibodies	>12 publications with JAM-A and Breast Neoplasms
Atherosclerosis Antibodies	>11 publications with JAM-A and Atherosclerosis
Disease Models, Animal Antibodies	>11 publications with JAM-A and Disease Models, Animal
Neoplasm Metastasis Antibodies	>8 publications with JAM-A and Neoplasm Metastasis
Heart Diseases Antibodies	>6 publications with JAM-A and Heart Diseases
Neoplasm Invasiveness Antibodies	>6 publications with JAM-A and Neoplasm Invasiveness
Lung Neoplasms Antibodies	>4 publications with JAM-A and Lung Neoplasms
Kidney Diseases Antibodies	>4 publications with JAM-A and Kidney Diseases

Organs/Tissues associated with anti-JAM-A antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>16 publications with JAM-A and Intestine
Brain Antibodies	>14 publications with JAM-A and Brain
Heart Antibodies	>14 publications with JAM-A and Heart
Lung Antibodies	>13 publications with JAM-A and Lung
Liver Antibodies	>12 publications with JAM-A and Liver
Muscle Antibodies	>10 publications with JAM-A and Muscle
Kidney Antibodies	>9 publications with JAM-A and Kidney
Embryonic Tissue Antibodies	>9 publications with JAM-A and Embryonic Tissue
Eye Antibodies	>6 publications with JAM-A and Eye
Skin Antibodies	>5 publications with JAM-A and Skin