Transferrin (TF) Antibody – Mouse Monoclonal

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: apical plasma membrane; basal plasma membrane; cell surface; clathrin-coated pit; clathrin-coated vesicle membrane; cytoplasmic vesicle; early endosome; endocytic vesicle; endoplasmic reticulum lumen; endosome membrane; extracellular region; extracellular space; extrinsic to external side of plasma membrane; late endosome; perinuclear region of cytoplasm; recycling endosome; vesicle

Molecular Function: ferric iron binding; ferric iron transmembrane transporter activity; ferrous iron binding; protein binding

Biological Process: cellular iron ion homeostasis; cellular protein metabolic process; iron ion homeostasis; platelet degranulation; positive regulation of receptor-mediated endocytosis; post-translational protein modification; regulation of protein stability; retinal homeostasis; transferrin transport

Disease: Atransferrinemia