Mouse NGF-beta Active Protein – Cat# MBS691763

NGF-beta Mouse Active Protein

Name: NGF-beta Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS691763
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691763

beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. beta-NGF is a potent neurotrophic factor that signals through its… More details

$305 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NGF-beta, Active Protein

Full Product Name

Mouse NGF-beta

Product Gene Name

NGF-beta active protein

Product Synonym Names

Recombinant Murine NGF-beta

Sequence

SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINN SVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL T TDEKQAAWR FIRIDTACVC VLSRKATRRG

Host

E Coli

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

> 98% by SDS-PAGE

Molecular Weight

13.4 kDa

Chromosome Location

Chromosome: 3; NC_000069.6 (102469919..102521013). Location: 3 F2.2; 3 45.25 cM

3D Structure

ModBase 3D Structure for P01139

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 0.1 ng per ug of NGF-beta

Biological Activity

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <= 1.0 ng/ml, corresponding to a specific activity of >= 1 x 106 units/mg.

Product Categories/Family for NGF-beta active protein

Cytokines & Growth Factors

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of NGF-beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NGF-beta purchase

MBS691763 is an active protein targeting NGF-beta. Also known as Mouse NGF-beta. Reactive in Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NGF-beta. It may not necessarily be applicable to this product.

NCBI GI #

162951831

NCBI GeneID

18049

NCBI Accession #

NP_001106168.1

UniProt Primary Accession #

P01139

UniProt Secondary Accession #

Q63864; Q6LDB7

UniProt Related Accession #

P01139

GenBank Nucleotide #

NM_001112698.2

NCBI Official Full Name

beta-nerve growth factor isoform B

NCBI Official Synonym Full Names

nerve growth factor

NCBI Official Symbol

Ngf

NCBI Official Synonym Symbols

Ngfb

UniProt Protein Name

Beta-nerve growth factor

UniProt Gene Name

Ngf

UniProt Synonym Gene Names

Ngfb; Beta-NGF

UniProt Entry Name

NGF_MOUSE

NCBI Protein Information

beta-nerve growth factor; beta-NGF; nerve growth factor, beta

UniProt Comments for NGF-beta

Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

Subunit structure: Homodimer.

Subcellular location: Secreted.

Sequence similarities: Belongs to the NGF-beta family.

Sequence caution: The sequence AAA37687.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA39818.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA39820.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA39821.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA24221.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on NGF-beta

1. calcineurin/NFAT pathway mediates the upregulation of PAI-1 by NGF

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NGF-beta active protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
Activation Of TRKA Receptors Pathway antibodies	Activation Of TRKA Receptors Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Signaling Pathway antibodies	Apoptosis Signaling Pathway Diagram
Axonal Growth Stimulation Pathway antibodies	Axonal Growth Stimulation Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Ceramide Signalling Pathway antibodies	Ceramide Signalling Pathway Diagram
Frs2-mediated Activation Pathway antibodies	Frs2-mediated Activation Pathway Diagram
Id Signaling Pathway antibodies	Id Signaling Pathway Diagram

Diseases associated with NGF-beta active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2071 publications with NGF-beta and Nervous System Diseases
Neurodegenerative Diseases Antibodies	>690 publications with NGF-beta and Neurodegenerative Diseases
Pain Antibodies	>676 publications with NGF-beta and Pain
Inflammation Antibodies	>649 publications with NGF-beta and Inflammation
Nerve Degeneration Antibodies	>586 publications with NGF-beta and Nerve Degeneration
Peripheral Nervous System Diseases Antibodies	>438 publications with NGF-beta and Peripheral Nervous System Diseases
Necrosis Antibodies	>434 publications with NGF-beta and Necrosis
Hyperalgesia Antibodies	>299 publications with NGF-beta and Hyperalgesia
Heart Diseases Antibodies	>107 publications with NGF-beta and Heart Diseases
Movement Disorders Antibodies	>104 publications with NGF-beta and Movement Disorders

Organs/Tissues associated with NGF-beta active protein

Organ/Tissue Name	Pubmed Publications
Salivary Gland Antibodies	>265 publications with NGF-beta and Salivary Gland
Lung Antibodies	>167 publications with NGF-beta and Lung
Kidney Antibodies	>155 publications with NGF-beta and Kidney
Bone Marrow Antibodies	>141 publications with NGF-beta and Bone Marrow
Connective Tissue Antibodies	>109 publications with NGF-beta and Connective Tissue
Thyroid Antibodies	>91 publications with NGF-beta and Thyroid
Testis Antibodies	>65 publications with NGF-beta and Testis