FADD ELISA Kit for Mouse

FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 7 F5|7 88.85 cM

Cellular Component: CD95 death-inducing signaling complex; cell body; cytoplasm; cytosol; membrane raft; neuron projection; nucleus; plasma membrane; protein complex

Molecular Function: caspase binding; death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; receptor serine/threonine kinase binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; cardiac muscle tissue development; defense response to virus; immune system process; innate immune response; lymph node development; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of apoptosis; response to morphine; signal transduction; spleen development; T cell differentiation; T cell differentiation in thymus; T cell homeostasis; thymus development; TRAIL-activated apoptotic signaling pathway