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Gelsolin (GSN) ELISA Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS267607

Principle of the Assay: As mentioned above, this kit utilizes the Double Antibody Sandwich ELISA technique. The pre-coated antibody is an anti-Mouse GS monoclonal antibody, while the detection antibody is a biotinylated polyclonal antibody. Samples and… More details

$350 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gelsolin (Gsn), ELISA Kit
Full Product Name
Mouse Gelsolin ELISA Kit
Product Gene Name
Gsn elisa kit
Species Reactivity
Mouse
Assay Type
Sandwich
Detection Range
100 ng/mL-1.56 ng/mL
Sensitivity
Up to 0.5 ng/mL
Specificity
No cross-reaction with other factors.
Preparation and Storage
Store all reagents at 2-8 degree C.
Inter-assay Precision
<= 12%
Intra-assay Precision
<= 8%
Molecular Weight
80,929 Da
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of Gsn elisa kit

Mouse GSN ELISA Kit – Cat# MBS267607

Other Notes

Small volumes of Gsn elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gsn purchase

MBS267607 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gelsolin (Gsn) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Gsn. The ELISA analytical biochemical technique of the MBS267607 kit is based on Gsn antibody-Gsn antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Gsn antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Gsn. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for Gsn. It may not necessarily be applicable to this product.

NCBI GI #
51854227
NCBI GeneID
296654
NCBI Accession #
NP_001004080.1
UniProt Related Accession #
Q68FP1
GenBank Nucleotide #
NM_001004080.1
NCBI Official Full Name
gelsolin
NCBI Official Synonym Full Names
gelsolin
NCBI Official Symbol
Gsn
UniProt Protein Name
Gelsolin
UniProt Synonym Protein Names
Actin-depolymerizing factor; ADF; Brevin
Protein Family
Gelsolin
UniProt Gene Name
Gsn
UniProt Synonym Gene Names
ADF
UniProt Entry Name
GELS_RAT
NCBI Protein Information
gelsolin; ADF; brevin; actin-depolymerizing factor

NCBI Summary for Gsn

plays a role in phosphoinositide mediated disassembly of actin filaments in Sertoli cell adhesion complexes; may regulate sperm release and turnover of the blood-testis barrier [RGD, Feb 2006]

UniProt Comments for Gsn

Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation.

Protein type: Secreted; Secreted, signal peptide; Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Cellular Component: ruffle; extracellular space; protein complex; focal adhesion; perinuclear region of cytoplasm; lamellipodium; extracellular region; cytosol; actin cytoskeleton

Molecular Function: calcium ion binding; actin binding

Biological Process: regulation of cell adhesion; actin filament severing; phosphoinositide-mediated signaling; wound healing; apoptosis; actin nucleation; vesicle-mediated transport; response to ethanol; tissue regeneration; actin filament polymerization; actin polymerization and/or depolymerization; response to folic acid; barbed-end actin filament capping; oligodendrocyte development; aging
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Research Articles on Gsn

1. It was concluded that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd-dependent activation of CaMK-IIdelta, binding of CaMK-IIdelta and gelsolin to actin filaments, and cleavage of gelsolin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Gsn elisa kit

 Reference Product  PubMed Publications
 Casp3 elisa kit  >5 publications with Gsn and Casp3
 Ttr elisa kit  >1 publications with Gsn and Ttr

Pathways associated with Gsn elisa kit

 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with Gsn elisa kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >23 publications with Gsn and Nervous System Diseases
 Neoplasms Antibodies  >17 publications with Gsn and Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with Gsn and Cardiovascular Diseases
 Inflammation Antibodies  >5 publications with Gsn and Inflammation
 Urinary Bladder Neoplasms Antibodies  >5 publications with Gsn and Urinary Bladder Neoplasms
 Heart Diseases Antibodies  >4 publications with Gsn and Heart Diseases
 Lung Diseases Antibodies  >3 publications with Gsn and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with Gsn and Carcinoma, Hepatocellular
 Drug Toxicity Antibodies  >2 publications with Gsn and Drug Toxicity
 Necrosis Antibodies  >2 publications with Gsn and Necrosis

Organs/Tissues associated with Gsn elisa kit

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >28 publications with Gsn and Nerve
 Brain Antibodies  >27 publications with Gsn and Brain
 Heart Antibodies  >8 publications with Gsn and Heart
 Liver Antibodies  >7 publications with Gsn and Liver
 Artery Antibodies  >5 publications with Gsn and Artery
 Lung Antibodies  >5 publications with Gsn and Lung
 Kidney Antibodies  >4 publications with Gsn and Kidney
 Embryonic Tissue Antibodies  >3 publications with Gsn and Embryonic Tissue
 Testis Antibodies  >2 publications with Gsn and Testis
 Dorsal Root Ganglion Antibodies  >2 publications with Gsn and Dorsal Root Ganglion
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