Telomerase Reverse Transcriptase (TERT) Mus Musculus (Mouse) Recombinant Protein

TERT: telomerase reverse transcriptase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The holoenzyme consists of TERT and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced isoforms have been identified, although the full-length sequence of some variants has not been determined.

Protein type: Transferase; Nucleolus; EC 2.7.7.49; DNA-binding

Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; mitochondrion; telomerase holoenzyme complex; cytoplasm; chromosome; ribonucleoprotein complex; nucleus

Molecular Function: transferase activity; telomerase activity; protein binding; RNA-directed RNA polymerase activity; protein homodimerization activity; DNA binding; metal ion binding; telomeric DNA binding; RNA-directed DNA polymerase activity; telomeric template RNA reverse transcriptase activity; tRNA binding; nucleotidyltransferase activity

Biological Process: mitochondrion organization and biogenesis; DNA strand elongation; positive regulation of hair cycle; RNA-dependent DNA replication; positive regulation of nitric-oxide synthase activity; telomere maintenance via telomerase; age-dependent telomere shortening; RNA interference, production of siRNA; positive regulation of Wnt receptor signaling pathway