FGF1 Mouse Recombinant Protein

FGF1: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; nucleolus; nucleoplasm; nucleus; proteinaceous extracellular matrix

Molecular Function: fibroblast growth factor receptor binding; growth factor activity; heparin binding; Hsp70 protein binding; integrin binding; protein binding

Biological Process: activation of MAPK activity; activation of protein kinase B; cardiac muscle cell proliferation; cell proliferation; fibroblast growth factor receptor signaling pathway; induction of an organ; lung development; positive regulation of angiogenesis; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cholesterol biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent