Complement C4 (C4A) Native Protein

Name: C4A Native Protein; Complement C4; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS355503
Price: 285 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355503

MBS355503 is a native protein targeting C4a. Also known as Complement C4 Protein (Active). Host: Human tissue. Purified human Complement C4 protein. More details

$285 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complement C4 (C4a), Native Protein

Full Product Name

Complement C4 Protein (Active)

Product Gene Name

C4a native protein

Host

Human tissue

Form/Format

Liquid

Purity/Purification

>90% by SDS-PAGE

Preparation and Storage

Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.

Molecular Weight

192,163 Da

Chromosome Location

Chromosome: 20; NC_005119.3 (4754468..4755821, complement). Location: 20p12

3D Structure

ModBase 3D Structure for P08649

Storage Buffer

Each vial contains 10mM PBS (pH7.4).

Applications Tested/Suitable for C4a native protein

ELISA (EIA)

Other Notes

Small volumes of C4a native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C4a. It may not necessarily be applicable to this product.

NCBI GI #

158186621

NCBI GeneID

24233

NCBI Accession #

NP_113692.2

UniProt Primary Accession #

P08649

UniProt Secondary Accession #

Q62895; Q8R403

UniProt Related Accession #

P08649

GenBank Nucleotide #

NM_031504.3

NCBI Official Full Name

complement C4

NCBI Official Synonym Full Names

complement component 4A (Rodgers blood group)

NCBI Official Symbol

C4a

NCBI Official Synonym Symbols

C4; C4b; C4-1

UniProt Protein Name

Complement C4

Protein Family

Complement C4

UniProt Gene Name

UniProt Synonym Gene Names

C4a

UniProt Entry Name

CO4_RAT

NCBI Protein Information

complement C4; complement component 4, gene 1; complement component 4 (within H-2S); complement component 4B (Chido blood group); complement component 4B (Childo blood group)

NCBI Summary for C4a

complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD, Feb 2006]

UniProt Comments for C4a

Function: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes

By similarity.Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Subunit structure: This protein is synthesized as a single-chain precursor and, prior to secretion, is enzymatically cleaved to form a trimer of non-identical chains alpha, beta and gamma.

Subcellular location: Secreted.

Induction: Induced in hepatic stellate cells by iron overload and by gamma-interferon. Ref.3

Miscellaneous: C4 is a major histocompatibility complex class-III protein.

Sequence similarities: Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain.

Sequence caution: The sequence AAA91231.1 differs from that shown. Reason: Frameshift at position 1721.

Research Articles on C4a

1. C3 and C4 may be involved in the immunopathology of allergic rhinitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C4a native protein

Reference Product	PubMed Publications
C1s native protein	>28 publications with C4a and C1s
C1r native protein	>6 publications with C4a and C1r
C1qb native protein	>1 publications with C4a and C1qb
C4bpa native protein	>1 publications with C4a and C4bpa
Masp2 native protein	>1 publications with C4a and Masp2

Pathways associated with C4a native protein

Products by Pathway	Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram

Diseases associated with C4a native protein

Disease Name	Pubmed Publications
Lupus Erythematosus, Systemic Antibodies	>157 publications with C4a and Lupus Erythematosus, Systemic
Inflammation Antibodies	>86 publications with C4a and Inflammation
Nervous System Diseases Antibodies	>59 publications with C4a and Nervous System Diseases
Kidney Diseases Antibodies	>51 publications with C4a and Kidney Diseases
Hyperplasia Antibodies	>43 publications with C4a and Hyperplasia
Gonadal Disorders Antibodies	>37 publications with C4a and Gonadal Disorders
Disorders of Sex Development Antibodies	>36 publications with C4a and Disorders of Sex Development
Necrosis Antibodies	>32 publications with C4a and Necrosis
Liver Diseases Antibodies	>32 publications with C4a and Liver Diseases
Heart Diseases Antibodies	>32 publications with C4a and Heart Diseases

Organs/Tissues associated with C4a native protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>64 publications with C4a and Liver
Kidney Antibodies	>49 publications with C4a and Kidney
Artery Antibodies	>30 publications with C4a and Artery
Heart Antibodies	>30 publications with C4a and Heart
Lung Antibodies	>24 publications with C4a and Lung
Brain Antibodies	>16 publications with C4a and Brain
Connective Tissue Antibodies	>10 publications with C4a and Connective Tissue
Pancreas Antibodies	>6 publications with C4a and Pancreas
Spleen Antibodies	>5 publications with C4a and Spleen
Prostate Antibodies	>4 publications with C4a and Prostate