SRC1 Antibody (N-Term) Blocking Peptide

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described.

Protein type: Nuclear receptor co-regulator; Acetyltransferase; Oncoprotein; EC 2.3.1.48; Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: enzyme binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity

Biological Process: bile acid and bile salt transport; cellular lipid metabolic process; cellular response to hormone stimulus; intracellular receptor-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent