• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us
Showing 451 to 500 of 1338 found results for "Classical Antibody-mediated Complement Activation Pathway"
Ig gamma-4 chain C region (IGHG4)

Chicken Ig gamma-4 chain C region (IGHG4) ELISA Kit

(#MBS7233218)

Gene Names:
IGHG4
Other Names:
Ig gamma-4 chain C region; partial; immunoglobulin heavy constant gamma 4 (G4m marker)
Host/Reactivities:
Reactivity: Chicken
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
C1QB

C1QB cDNA Clone

(#MBS1268589)

Gene Names:
C1QB
Other Names:
Homo sapiens complement component 1; q subcomponent; B chain; mRNA; complement C1q B chain
C Reactive Protein (CRP)

Cy3-Linked Monoclonal Antibody to C Reactive Protein (CRP)

(#MBS2048169)

Gene Names:
CRP; PTX1
Other Names:
C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Host: Mouse / Reactivity: Human, Rat
Isotype/Clone:
Isotype: IgG1 Kappa / Clone E1
Applications:
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)
C Reactive Protein (CRP)

PE-Linked Polyclonal Antibody to C Reactive Protein (CRP)

(#MBS2048148)

Gene Names:
CRP; PTX1
Other Names:
C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Host: Rabbit / Reactivity: Mouse, Rat
Applications:
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
Typical Testing Data/Standard Curve (for reference only)

Porcine Complement C1q subcomponent subunit C (C1QC) ELISA Kit

(#MBS7203576)

Gene Names:
C1QC; C1QG; C1Q-C
Other Names:
complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
Host/Reactivities:
Reactivity: Porcine
Assay Type
Quantitative Competitive
Samples
Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
Sensitivity
1.0 ng/mL
Immunoglobulin G2 (IgG2)

Human Immunoglobulin G2 (IgG2) ELISA Kit DIY Materials

(#MBS2089136)

Gene Names:
IgG2; IGHG2
Other Names:
Ig Gamma-2 Chain C Region; Immunoglobulin Heavy Constant Gamma 2; G2m Marker; Immunoglobulin Gm2; immunoglobulin heavy constant gamma 2 (G2m marker)
Host/Reactivities:
Reactivity: Human
C Reactive Protein (CRP)

APC/CY7-Linked Polyclonal Antibody to C Reactive Protein (CRP)

(#MBS2048117)

Gene Names:
CRP; PTX1
Other Names:
C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Host: Rabbit / Reactivity: Chicken
Applications:
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
Complement C1R HC

Complement C1R HC Antibody

(#MBS8583390)

Gene Names:
C1R
Other Names:
Complement C1r subcomponent; Complement component 1 subcomponent r; complement component 1; r subcomponent
Host/Reactivities:
Host: Rabbit / Reactivity: Human, Mouse, Rat
Purification:
The antibody was purified by immunogen affinity chromatography.
Isotype/Clone:
Isotype: IgG
Applications:
Western Blot (WB)
IGHG1

IGHG1 cDNA Clone

(#MBS1277590)

Gene Names:
IGHG1
Other Names:
Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker); mRNA; immunoglobulin heavy constant gamma 1 (G1m marker)
Typical Testing Data/Standard Curve (for reference only)

Human C-Reactive Protein (CRP) ELISA Kit

(#MBS3800117)

Gene Names:
CRP; PTX1
Other Names:
C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Reactivity: Human
Assay Type
Sandwich
Samples
Serum, plasma, cell culture supernate and other biological fluids
Detection Range
0.75 mg/L-12 mg/L
Sensitivity
0.1 mg/L
Complement C1s subcomponent (C1S)

Rat Complement C1s subcomponent (C1S) ELISA Kit

(#MBS7248148)

Gene Names:
C1S
Other Names:
complement C1s subcomponent; complement component 1; s subcomponent
Host/Reactivities:
Reactivity: Rat
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
SDS-PAGE

Recombinant Human IgG4-Fc Protein (108 Ser/Pro)

(#MBS2545296)

Gene Names:
IgG4-Fc; IGHG4
Other Names:
IgG4; Ig gamma-4 chain C region; immunoglobulin heavy constant gamma 4 (G4m marker)
Host/Reactivities:
Host: Human Cells
Purity:
> 95 % as determined by SDS-PAGE
C Reactive Protein (CRP)

Cy3-Linked Polyclonal Antibody to C Reactive Protein (CRP)

(#MBS2048129)

Gene Names:
CRP; PTX1
Other Names:
C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Host: Rabbit / Reactivity: Guinea pig , Rat
Applications:
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
C Reactive Protein (CRP)

FITC-Linked Polyclonal Antibody to C Reactive Protein (CRP)

(#MBS2048121)

Gene Names:
CRP; PTX1
Other Names:
C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Host: Rabbit / Reactivity: Chicken
Applications:
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
Ig gamma-4 chain C region (IGHG4)

Rabbit Ig gamma-4 chain C region (IGHG4) ELISA Kit

(#MBS7212623)

Gene Names:
IGHG4
Other Names:
Ig gamma-4 chain C region; partial; immunoglobulin heavy constant gamma 4 (G4m marker)
Host/Reactivities:
Reactivity: Rabbit
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
C-reactive protein

Sheep C-reactive protein (CRP) ELISA Kit

(#MBS285696)

Gene Names:
CRP; PTX1
Other Names:
C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
Host/Reactivities:
Reactivity: Sheep
Assay Type
Sandwich
Samples
Serum, Plasma, Other biological fluids
  • Western Blot (WB)
  • Immunohistochemistry (IHC)

    Anti-Kappa light chain Antibody

    (#MBS8324636)

    Gene Names:
    IGKC; Km; HCAK1; IGKCD
    Other Names:
    Ig kappa chain C region; immunoglobulin kappa constant
    Host/Reactivities:
    Host: Mouse / Reactivity: Human
    Purification:
    This antibody is purified through a protein G column.
    Isotype/Clone:
    Isotype: Mouse IgG1 kappa
    Applications:
    Western Blot (WB), Immunohistochemistry (IHC)
    C Reactive Protein (CRP)

    Rat C Reactive Protein (CRP) ELISA Kit DIY Materials

    (#MBS2088841)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Reactivity: Rat
    Complement C1q subcomponent subunit C (C1QC)

    Chicken Complement C1q subcomponent subunit C (C1QC) ELISA Kit

    (#MBS7239276)

    Gene Names:
    C1QC; C1QG; C1Q-C
    Other Names:
    complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
    Host/Reactivities:
    Reactivity: Chicken
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    C Reactive Protein (CRP)

    APC/CY7-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048123)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Guinea pig , Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    Complement C1s subcomponent (C1S)

    Human Complement C1s subcomponent (C1S) ELISA Kit

    (#MBS7213782)

    Gene Names:
    C1S
    Other Names:
    complement C1s subcomponent; complement component 1; s subcomponent
    Host/Reactivities:
    Reactivity: Human
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    C Reactive Protein (CRP)

    PE-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048112)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Bovine, Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    C-Reactive Protein

    C-Reactive Protein, Recombinant, Human (Azide Free) (CRP, MGC88244, PTX 1, PTX1)

    (#MBS636777)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-reactive protein; pentraxin-related
    Purity:
    Highly PurifiedPurified by affinity chromatography. A band at ~23kD is detected by SDS-PAGE.
    IgG1

    IgG1 Blocking Peptide

    (#MBS824360)

    Gene Names:
    IGHG1
    Other Names:
    Ig gamma-1 chain C region; partial; immunoglobulin heavy constant gamma 1 (G1m marker)
    Host/Reactivities:
    Host: Synthetic / Reactivity: Human
    Purity:
    >85%
    Applications:
    Blocking (BL)
    C Reactive Protein (CRP)

    PE-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048136)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Human, Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    Ig gamma-4 chain C region (IGHG4)

    Guinea pig Ig gamma-4 chain C region (IGHG4) ELISA Kit

    (#MBS7234027)

    Gene Names:
    IGHG4
    Other Names:
    Ig gamma-4 chain C region; partial; immunoglobulin heavy constant gamma 4 (G4m marker)
    Host/Reactivities:
    Reactivity: Guinea Pig
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    Complement Component 1, S Subcomponent (C1s)

    HRP-Linked Polyclonal Antibody to Complement Component 1, S Subcomponent (C1s)

    (#MBS2057793)

    Gene Names:
    C1s; EDSPD2
    Other Names:
    C1 esterase; Complement component 1; s subcomponent; complement C1s
    Host/Reactivities:
    Host: Rabbit / Reactivity: Human, Mouse, Rat, Pig
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    C Reactive Protein (CRP)

    HRP-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048145)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Human, Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    Typical Testing Data/Standard Curve (for reference only)

    QuicKey Pro Human CRP (C-Reactive Protein) ELISA Kit

    (#MBS2568086)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-Reactive Protein; pentraxin-related
    Host/Reactivities:
    Reactivity: Human
    Assay Type
    Quantitative Sandwich
    Samples
    Human serum and plasma samples
    Detection Range
    125-8000 pg/mL
    Sensitivity
    52.1 pg/mL
    C-reactive protein

    Goat anti Human C-reactive protein

    (#MBS573261)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-reactive protein; pentraxin-related
    Host/Reactivities:
    Host: Goat / Reactivity: Human
    Applications:
    Immunoprecipitation (IP)
    C Reactive Protein (CRP)

    HRP-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048132)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Guinea pig , Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    C Reactive Protein (CRP)

    PE-Linked Monoclonal Antibody to C Reactive Protein (CRP)

    (#MBS2118404)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein
    Host/Reactivities:
    Host: Mouse / Reactivity: Human, Rat
    Purification:
    Protein A + Protein G Affinity Chromatography
    Isotype/Clone:
    Isotype: IgG2a Kappa / Clone E7
    Applications:
    Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
    Complement C1s subcomponent (C1S)

    Sheep Complement C1s subcomponent (C1S) ELISA Kit

    (#MBS7207905)

    Gene Names:
    C1S
    Other Names:
    complement C1s subcomponent; complement component 1; s subcomponent
    Host/Reactivities:
    Reactivity: Sheep
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    Complement C1q subcomponent subunit C (C1QC)

    Guinea pig Complement C1q subcomponent subunit C (C1QC) ELISA Kit

    (#MBS7242790)

    Gene Names:
    C1QC; C1QG; C1Q-C
    Other Names:
    complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
    Host/Reactivities:
    Reactivity: Guinea Pig
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    IGHG1

    IGHG1 cDNA Clone

    (#MBS1266915)

    Gene Names:
    IGHG1
    Other Names:
    Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker); mRNA; immunoglobulin heavy constant gamma 1 (G1m marker)
    Complement C1q subcomponent subunit C (C1QC)

    Human Complement C1q subcomponent subunit C (C1QC) ELISA Kit

    (#MBS7204846)

    Gene Names:
    C1QC; C1QG; C1Q-C
    Other Names:
    complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
    Host/Reactivities:
    Reactivity: Human
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    C1QG

    C1QG Rabbit pAb

    (#MBS8575818)

    Gene Names:
    C1QG; C1QC; C1Q-C
    Other Names:
    complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
    Host/Reactivities:
    Host: Rabbit / Reactivity: Human
    Purification:
    Affinity purified
    Isotype/Clone:
    Isotype: Rabbit IgG
    Applications:
    Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
    Kappa Light Chain

    Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin Kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 490)

    (#MBS6201492)

    Gene Names:
    IGKC
    Other Names:
    Homo sapiens immunoglobulin kappa constant; mRNA
    Host/Reactivities:
    Host: Mouse / Reactivity: Human
    Purification:
    Purified by Protein A Affinity Chromatography.
    Isotype/Clone:
    Isotype: IgG2a,k / Clone 1F6
    Applications:
    FLISA, Western Blot (WB)
    IGKV1-5

    IGKV1-5 cDNA Clone

    (#MBS1276573)

    Gene Names:
    IGKV1-5; V1; L12; IGKV; L12a; IGKV15
    Other Names:
    Homo sapiens immunoglobulin kappa variable 1-5; mRNA; immunoglobulin kappa variable 1-5
    Complement C1q subcomponent subunit C (C1QC)

    Rabbit Complement C1q subcomponent subunit C (C1QC) ELISA Kit

    (#MBS7235896)

    Gene Names:
    C1QC; C1QG; C1Q-C
    Other Names:
    complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
    Host/Reactivities:
    Reactivity: Rabbit
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    C Reactive Protein (CRP)

    HRP-Linked Monoclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048171)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Mouse / Reactivity: Human, Rat
    Isotype/Clone:
    Isotype: IgG1 Kappa / Clone E1
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)
    C-Reactive Protein

    C-Reactive Protein, Recombinant, Human (CRP, MGC88244, PTX 1, PTX1)

    (#MBS636479)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-reactive protein; pentraxin-related
    Host/Reactivities:
    Host: E Coli
    Purity:
    Highly PurifiedPurified by affinity chromatography. A band at ~23kD is detected by SDS-PAGE.
    C Reactive Protein (CRP)

    Mouse C Reactive Protein (CRP) Antibody Pair Kit (with Standard)

    (#MBS2089997)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Reactivity: Mouse
    Applications:
    ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
    C Reactive Protein (CRP)

    PE-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048164)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Mouse, Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    C Reactive Protein (CRP)

    FITC-Linked Monoclonal Antibody to C Reactive Protein (CRP)

    (#MBS2114389)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein
    Host/Reactivities:
    Host: Mouse / Reactivity: Human, Rat
    Purification:
    Protein A + Protein G Affinity Chromatography
    Isotype/Clone:
    Isotype: IgG2a Kappa / Clone E7
    Applications:
    Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
    C Reactive Protein (CRP)

    HRP-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048122)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Chicken
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    Complement C1q subcomponent subunit C (C1QC)

    Monkey Complement C1q subcomponent subunit C (C1QC) ELISA Kit

    (#MBS7216391)

    Gene Names:
    C1QC; C1QG; C1Q-C
    Other Names:
    complement C1q subcomponent subunit C; complement component 1; q subcomponent; C chain
    Host/Reactivities:
    Reactivity: Monkey
    Samples
    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
    ELISA (EIA)

    Anti-C-Reactive Protein Mouse mAb

    (#MBS477206)

    Gene Names:
    CRP; PTX1
    Other Names:
    Pentraxin 1; short; C reactive protein; C reactive protein pentraxin related; C-reactive protein (1-205); CRP_HUMAN; MGC88244; PTX 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Mouse / Reactivity: Human
    Purification:
    Affinity Purified
    Isotype/Clone:
    Isotype: lgG2b / Clone 6D1-A10
    Applications:
    ELISA (EIA)
    C Reactive Protein (CRP)

    PE-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048125)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Guinea pig , Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
    C Reactive Protein (CRP)

    APC-Linked Polyclonal Antibody to C Reactive Protein (CRP)

    (#MBS2048166)

    Gene Names:
    CRP; PTX1
    Other Names:
    C-RP; Pentraxin-Related; Pentraxin 1; C-reactive protein isoform 1; C-reactive protein
    Host/Reactivities:
    Host: Rabbit / Reactivity: Mouse, Rat
    Applications:
    Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

    • Products by Diseases
    • IgG Antibody
    • Monoclonal Antibody
    • Polyclonal Antibody
    • Peptide
    • Recombinant Protein
    • Secondary Antibody
    • MyBioSource
    Request a Quote

    Please fill out the form below and our representative will get back to you shortly.

    MBS000000
    Contact Us

    Please fill out the form below and our representative will get back to you shortly.

    MBS000000