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PHLPP2 Immunizing Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS425064

MBS425064 is a blocking peptide targeting PHLPPL. Also known as PHLPP2 Immunizing Peptide. Reactive in Human. More details

$245 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PHLPP2 (PHLPPL), Blocking Peptide
Full Product Name
PHLPP2 Immunizing Peptide
Product Gene Name
PHLPPL blocking peptide
Product Synonym Gene Name
PHLPP2
Product Synonym Names
PHLPP2; PHLPPL; PH domain and leucine rich repeat protein phosphatase-like; KIAA0931
Sequence
C-PHEEDRTE PPEEFD
Species Reactivity
Human
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
Antibody/Peptide Pairs
PHLPP2 peptide (MBS425064) is used for blocking the activity of PHLPP2 antibody (MBS421467)
Molecular Weight
139,394 Da
OMIM
611066
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of PHLPPL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PHLPPL. It may not necessarily be applicable to this product.

NCBI GI #
65301141
NCBI GeneID
23035
NCBI Accession #
NP_055835.2
UniProt Secondary Accession #
Q9NV17; Q9Y2E3; A1L374
UniProt Related Accession #
Q6ZVD8
GenBank Nucleotide #
NM_015020.3
NCBI Official Full Name
PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1
NCBI Official Synonym Full Names
PH domain and leucine rich repeat protein phosphatase 2
NCBI Official Symbol
PHLPP2
NCBI Official Synonym Symbols
PPM3B; PHLPPL
UniProt Protein Name
PH domain leucine-rich repeat-containing protein phosphatase 2
UniProt Synonym Protein Names
PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like
UniProt Gene Name
PHLPP2
UniProt Synonym Gene Names
KIAA0931; PHLPPL; PHLPP-like
UniProt Entry Name
PHLP2_HUMAN
NCBI Protein Information
PH domain leucine-rich repeat-containing protein phosphatase 2

UniProt Comments for PHLPPL

PHLPP2: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: cytoplasm; cytosol; nucleus; photoreceptor inner segment

Molecular Function: metal ion binding; protein serine/threonine phosphatase activity

Biological Process: hippocampus development; protein amino acid dephosphorylation
Show more

Research Articles on PHLPPL

1. Data show that both serine/threonine phosphatases PHLPP and dephosphorylated the physiological substrates of Akt1 and Akt3 with similar efficiencies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PHLPPL blocking peptide

 Reference Product  PubMed Publications
 PHLPP1 blocking peptide  >31 publications with PHLPPL and PHLPP1
 AKT1 blocking peptide  >7 publications with PHLPPL and AKT1
 AKT2 blocking peptide  >2 publications with PHLPPL and AKT2
 AKT3 blocking peptide  >2 publications with PHLPPL and AKT3

Pathways associated with PHLPPL blocking peptide

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
 Downstream Signaling Of Activated FGFR2 Pathway antibodies  Downstream Signaling Of Activated FGFR2 Pathway Diagram
 Downstream Signaling Of Activated FGFR3 Pathway antibodies  Downstream Signaling Of Activated FGFR3 Pathway Diagram
 Downstream Signaling Of Activated FGFR4 Pathway antibodies  Downstream Signaling Of Activated FGFR4 Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram

Diseases associated with PHLPPL blocking peptide

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >4 publications with PHLPPL and Adenocarcinoma
 Inflammation Antibodies  >4 publications with PHLPPL and Inflammation
 Immune System Diseases Antibodies  >3 publications with PHLPPL and Immune System Diseases
 Lung Diseases Antibodies  >3 publications with PHLPPL and Lung Diseases
 Lung Neoplasms Antibodies  >3 publications with PHLPPL and Lung Neoplasms
 Disease Models, Animal Antibodies  >2 publications with PHLPPL and Disease Models, Animal
 Vascular Diseases Antibodies  >2 publications with PHLPPL and Vascular Diseases
 Insulin Resistance Antibodies  >2 publications with PHLPPL and Insulin Resistance
 Fatty Liver Antibodies  >2 publications with PHLPPL and Fatty Liver
 Necrosis Antibodies  >1 publications with PHLPPL and Necrosis

Organs/Tissues associated with PHLPPL blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >6 publications with PHLPPL and Prostate
 Muscle Antibodies  >4 publications with PHLPPL and Muscle
 Blood Antibodies  >4 publications with PHLPPL and Blood
 Liver Antibodies  >4 publications with PHLPPL and Liver
 Brain Antibodies  >4 publications with PHLPPL and Brain
 Lymph Node Antibodies  >3 publications with PHLPPL and Lymph Node
 Eye Antibodies  >2 publications with PHLPPL and Eye
 Intestine Antibodies  >2 publications with PHLPPL and Intestine
 Vascular Antibodies  >1 publications with PHLPPL and Vascular
 Skin Antibodies  >1 publications with PHLPPL and Skin
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