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Cytochrome P450 4a11 (CYP4A11) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS837238

MBS837238 is an antibody targeting CYP4A11. Also known as Cytochrome P450 4A11 antibody. Host: Rabbit. Affinity purified Rabbit polyclonal Cytochrome P450 4A11 antibody More details

$1565 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Cytochrome P450 4A11 (CYP4A11), Polyclonal Antibody
Full Product Name
Cytochrome P450 4A11 antibody
Product Gene Name
anti-CYP4A11 antibody
Product Synonym Names
Polyclonal Cytochrome P450 4A11; Anti-Cytochrome P450 4A11; CP4Y; 20-hydroxyeicosatetraenoic acid synthase; CYP4AII; Cytochrome P 4A11 450; cytochrome P450 subfamily IVA polypeptide 11; Cytochrome P 4A11-450; Cytochrome P450 4A11; CYPIVA11; cytochrome P450HL-omega; CYP4A11; CYP4A2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
Purity/Purification
Cytochrome P450 4A11 antibody was purified by antigen-affinity chromatography
Concentration
0.57 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
59 kDa
OMIM
601310
3D Structure
ModBase 3D Structure for Q02928
Cross-Reactivity
Human
Immunogen
Cytochrome P450 4A11 antibody was raised in rabbit using a recombinant fragment corresponding to a region within amino acids 48 and 316 of Cytochrome P450 4A11

Product Categories/Family for anti-CYP4A11 antibody

Proteases; Inhibitors; & Enzymes; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-CYP4A11 antibody
Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-CYP4A11 antibody
IF:1:100-1:200
IHC-P: 1:100-1:250
ICC:1:100-1:200
WB: 1:500-1:3000

Immunofluorescence (IF) of anti-CYP4A11 antibody

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Cytochrome P450 4A11 antibody at 1:200 dilution.
Rabbit Anti-CYP4A11 Polyclonal Antibody – Cat# MBS837238

Western Blot (WB) of anti-CYP4A11 antibody

Western blot analysis of 30 ug of whole cell lysate (A:A431; B:H1299) using a 7.5 % SDS PAGE gel and Cytochrome P450 4A11 antibody at a dilution of 1:100
Rabbit Anti-CYP4A11 Polyclonal Antibody, Western Blot (WB) – Cat# MBS837238

Immunohistochemistry (IHC) of anti-CYP4A11 antibody

Immunohistochemical staining of paraffin-embedded mixed OVCA using Cytochrome P450 4A11 antibody at a dilution of 1:100
Rabbit Anti-CYP4A11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS837238

Other Notes

Small volumes of anti-CYP4A11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP4A11. It may not necessarily be applicable to this product.

NCBI GI #
158937242
NCBI GeneID
1579
NCBI Accession #
NP_000769.2
UniProt Primary Accession #
Q02928
UniProt Secondary Accession #
Q06766; Q16865; Q16866; Q5VSP8; Q86SU6; Q8IWY5
UniProt Related Accession #
Q02928
GenBank Nucleotide #
NM_000778.3
NCBI Official Full Name
cytochrome P450 4A11
NCBI Official Synonym Full Names
cytochrome P450, family 4, subfamily A, polypeptide 11
NCBI Official Symbol
CYP4A11
NCBI Official Synonym Symbols
CP4Y; CYP4A2; CYP4AII
UniProt Protein Name
Cytochrome P450 4A11
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase (EC:1.14.15.3)
Protein Family
Cytochrome
UniProt Gene Name
CYP4A11
UniProt Synonym Gene Names
CYP4A2; 20-HETE synthase
UniProt Entry Name
CP4AB_HUMAN
NCBI Protein Information
cytochrome P450 4A11

NCBI Summary for CYP4A11

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYP4A11

CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Lipid Metabolism - fatty acid; Cofactor and Vitamin Metabolism - retinol; EC 1.14.15.3; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm

Molecular Function: leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity

Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; renal water homeostasis; arachidonic acid metabolic process; epoxygenase P450 pathway; sodium ion homeostasis; leukotriene metabolic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; pressure natriuresis
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Research Articles on CYP4A11

1. individuals homozygous for the CYP4A11 rs3890011 C allele, blood pressure is resistant to mineralocorticoid receptor antagonism, but sensitive to ENaC inhibition, consistent with ENaC activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYP4A11 antibody

 Reference Product  PubMed Publications
 CYP2E1 antibody  >32 publications with CYP4A11 and CYP2E1
 CYP2C9 antibody  >20 publications with CYP4A11 and CYP2C9
 CYP2B6 antibody  >20 publications with CYP4A11 and CYP2B6
 CYP2C8 antibody  >19 publications with CYP4A11 and CYP2C8
 CYP1A2 antibody  >18 publications with CYP4A11 and CYP1A2
 CYP2C19 antibody  >16 publications with CYP4A11 and CYP2C19
 CYP2A6 antibody  >15 publications with CYP4A11 and CYP2A6
 CYP1A1 antibody  >14 publications with CYP4A11 and CYP1A1

Pathways associated with anti-CYP4A11 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Eicosanoids Pathway antibodies  Eicosanoids Pathway Diagram
 Fatty Acid Omega Oxidation Pathway antibodies  Fatty Acid Omega Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram

Diseases associated with anti-CYP4A11 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >18 publications with CYP4A11 and Fatty Liver
 Liver Diseases Antibodies  >9 publications with CYP4A11 and Liver Diseases
 Inflammation Antibodies  >6 publications with CYP4A11 and Inflammation
 Brain Diseases Antibodies  >5 publications with CYP4A11 and Brain Diseases
 Liver Neoplasms Antibodies  >4 publications with CYP4A11 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with CYP4A11 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >2 publications with CYP4A11 and Kidney Diseases
 Hemorrhage Antibodies  >2 publications with CYP4A11 and Hemorrhage
 Neoplasm Metastasis Antibodies  >2 publications with CYP4A11 and Neoplasm Metastasis
 Lung Diseases Antibodies  >2 publications with CYP4A11 and Lung Diseases

Organs/Tissues associated with anti-CYP4A11 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >55 publications with CYP4A11 and Liver
 Blood Antibodies  >37 publications with CYP4A11 and Blood
 Kidney Antibodies  >29 publications with CYP4A11 and Kidney
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