GRIP1 Antibody – Rabbit Polyclonal

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

GRIP1: a scaffold protein for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific locations in neurons. Interacts with EphA7, EphB2, KIF5A, -B, -C, GluR2, -3, GRIPAP1, liprin A1, PPFIA4, FRAS1, and PTPRF.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: postsynaptic membrane; recycling endosome; neuron projection; endoplasmic reticulum; dendrite; cytoplasmic membrane-bound vesicle; plasma membrane; cytosol; cell junction; lipid raft

Molecular Function: protein C-terminus binding; protein binding; receptor signaling complex scaffold activity; androgen receptor binding; transcription coactivator activity; beta-catenin binding; glucocorticoid receptor binding

Biological Process: synaptic transmission; protein localization; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; dendrite development

Disease: Fraser Syndrome