HTR1A Antibody – Rabbit Polyclonal

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; serotonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; vasoconstriction; cell proliferation; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; regulation of hormone secretion; serotonin metabolic process; serotonin receptor signaling pathway; regulation of behavior

Disease: Periodic Fever, Menstrual Cycle-dependent