lktA Antibody – Rabbit Polyclonal

Function: Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca2+ and lysis of the host cell

By similarity. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also weak hemolytic activity.

Subcellular location: Secreted

By similarity. Host cell membrane; Multi-pass membrane protein

By similarity.

Domain: The transmembrane domains are believed to be involved in pore formation in target cells

By similarity.The Gly-rich region is probably involved in calcium binding, which is required for target cell-binding and cytolytic activity

By similarity.The C-terminal domain contains an export signal that is recognized by the ABC transporter complex LktBD

By similarity.

Post-translational modification: Acylated by LktC. The toxin only becomes active when modified

By similarity.

Miscellaneous: The lktCABD operon has a complex mosaic structure that has been derived by extensive inter- and intraspecies horizontal DNA transfer and intragenic recombination events.

Sequence similarities: Belongs to the RTX prokaryotic toxin (TC 1.C.11) family. [View classification]Contains 5 hemolysin-type calcium-binding repeats.