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PARD6A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6388436

PAR6 is a cell membrane protein involved in cell polarization and asymmetrical cell division processes as part of a multi protein complex. It is thought to be involved in the invasive phenotype that is associated with metastatic carcinomas, playing a role in… More details

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Product Overview

Online Datasheet in PDF
Product Name
PARD6A, Polyclonal Antibody
Full Product Name
PARD6A (Partitioning Defective 6 Homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax Interaction Protein 40, TIP-40, PAR6A, TAX40) (PE)
Product Gene Name
anti-PARD6A antibody
Immunogen Sequence
MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH QIPGLDVLLG YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKREADSS GLAFASNSLQ RRKKGLLLRP VAPLRTRPPL LISLPQDFRQ VSSVIDVDLL PETHRRVRLH KHGSDRPLGF YIRDGMSVRV APQGLERVPG IFISRLVRGG LAESTGLLAV SDEILEVNGI EVAGKTLDQV TDMMVANSHN LIVTVKPANQ RNNVVRGASG RLTGPPSAGP GPAEPDSDDD SSDLVIENRQ PPSSNGLSQG PPCWDLHPGC RHPGTRSSLP SLDDQEQASS GWGSRIRGDG SGFSL
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Concentration
0.9mg/mL (lot specific)
Specificity
Recognizes human PARD6A. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Chromosome Location
Chromosome: 16; NC_000016.9 (67694851..67696681). Location: 16q22.1
OMIM
607484
3D Structure
ModBase 3D Structure for Q9NPB6
Immunogen
Full length recombinant protein corresponding to aa1-345 from human PARD6A.
Type
Pab
Note
Preservative Free

Product Categories/Family for anti-PARD6A antibody

Antibodies; Cell Division Cycle (CDC)
Applications Tested/Suitable for anti-PARD6A antibody
Western Blot (WB)
Application Notes for anti-PARD6A antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PARD6A antibody

PARD6A rabbit polyclonal antibody. Western Blot analysis of PARD6A expression in mouse kidney using MBS6388436.
Rabbit Anti-PARD6A Polyclonal Antibody – Cat# MBS6388436

Western Blot (WB) of anti-PARD6A antibody

Western Blot analysis of PARD6A expression in transfected 293T cell line MBS6388436. Lane 1: PARD6A transfected lysate (37.3kD). Lane 2: Non-transfected lysate.
Rabbit Anti-PARD6A Polyclonal Antibody, Western Blot (WB) – Cat# MBS6388436

Other Notes

Small volumes of anti-PARD6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PARD6A purchase

MBS6388436 is an antibody targeting PARD6A. Also known as PARD6A (Partitioning Defective 6 Homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax Interaction Protein 40, TIP-40, PAR6A, TAX40) (PE). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PARD6A. It may not necessarily be applicable to this product.

NCBI GI #
82659097
NCBI GeneID
50855
NCBI Accession #
NP_001032358.1
UniProt Primary Accession #
Q9NPB6
UniProt Secondary Accession #
O14911; Q9NPJ7
UniProt Related Accession #
Q9NPB6
GenBank Nucleotide #
NM_001037281
NCBI Official Full Name
partitioning defective 6 homolog alpha isoform 2
NCBI Official Synonym Full Names
par-6 family cell polarity regulator alpha
NCBI Official Symbol
PARD6A
NCBI Official Synonym Symbols
PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha
UniProt Protein Name
Partitioning defective 6 homolog alpha
UniProt Synonym Protein Names
PAR6C; Tax interaction protein 40; TIP-40
Protein Family
Partitioning defective
UniProt Gene Name
PARD6A
UniProt Synonym Gene Names
PAR6A; PAR-6; PAR-6 alpha; PAR-6A; TIP-40
UniProt Entry Name
PAR6A_HUMAN
NCBI Protein Information
partitioning defective 6 homolog alpha; PAR-6 alpha; Tax-interacting protein 40; tax interaction protein 40; partitioning-defective protein 6; partitioning defective-6 homolog alpha; par-6 partitioning defective 6 homolog alpha

UniProt Comments for PARD6A

PARD6A: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Interacts with MAP2K5. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr- 359' phosphorylated form) and PRKCI. Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. Belongs to the PAR6 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: ruffle; protein complex; tight junction; apical part of cell; plasma membrane; cell cortex; nucleus; cytosol

Molecular Function: protein binding; Rho GTPase binding; protein kinase C binding; GTP-dependent protein binding; transcription factor binding

Biological Process: intercellular junction assembly and maintenance; viral reproduction; cell division; transforming growth factor beta receptor signaling pathway; intercellular junction maintenance; cell cycle
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PARD6A antibody

 Reference Product  PubMed Publications
 PARD3 antibody  >18 publications with PARD6A and PARD3
 CDC42 antibody  >12 publications with PARD6A and CDC42
 RAC1 antibody  >5 publications with PARD6A and RAC1
 PRKCZ antibody  >2 publications with PARD6A and PRKCZ
 TIAM1 antibody  >1 publications with PARD6A and TIAM1

Pathways associated with anti-PARD6A antibody

 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway antibodies  Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway Diagram

Diseases associated with anti-PARD6A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with PARD6A and Neoplasms
 Carcinoma Antibodies  >10 publications with PARD6A and Carcinoma
 Lung Neoplasms Antibodies  >7 publications with PARD6A and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >4 publications with PARD6A and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >3 publications with PARD6A and Breast Neoplasms
 Inflammation Antibodies  >2 publications with PARD6A and Inflammation
 Necrosis Antibodies  >2 publications with PARD6A and Necrosis
 Liver Diseases Antibodies  >1 publications with PARD6A and Liver Diseases
 Neoplasm Metastasis Antibodies  >1 publications with PARD6A and Neoplasm Metastasis
 Precancerous Conditions Antibodies  >1 publications with PARD6A and Precancerous Conditions

Organs/Tissues associated with anti-PARD6A antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with PARD6A and Lung
 Kidney Antibodies  >9 publications with PARD6A and Kidney
 Blood Antibodies  >3 publications with PARD6A and Blood
 Brain Antibodies  >3 publications with PARD6A and Brain
 Intestine Antibodies  >2 publications with PARD6A and Intestine
 Eye Antibodies  >2 publications with PARD6A and Eye
 Parathyroid Antibodies  >1 publications with PARD6A and Parathyroid
 Liver Antibodies  >1 publications with PARD6A and Liver
 Prostate Antibodies  >1 publications with PARD6A and Prostate
 Nerve Antibodies  >1 publications with PARD6A and Nerve
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