RBM5 Antibody – Rabbit Polyclonal

RBM5: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. Belongs to the RBM5/RBM10 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; C2H2-type zinc finger protein; Cell cycle regulation; RNA processing; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; nucleus; spliceosome

Molecular Function: DNA binding; mRNA binding; protein binding; RNA binding

Biological Process: negative regulation of cell proliferation; nuclear mRNA splicing, via spliceosome; positive regulation of apoptosis; regulation of alternative nuclear mRNA splicing, via spliceosome; RNA processing; spliceosome assembly