RHAG Antibody – Rabbit Polyclonal

The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]

RHAG: Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Defects in RHAG are the cause of regulator type Rh-null hemolytic anemia (RHN); also known as Rh-deficiency syndrome. RHN is a form of chronic hemolytic anemia in which the red blood cells have a stomatocytosis and spherocytosis morphology, an increased osmotic fragility, an altered ion transport system, and abnormal membrane phospholipid organization. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p12.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ammonium transmembrane transporter activity; ankyrin binding

Biological Process: erythrocyte development; bicarbonate transport; cellular ion homeostasis; carbon dioxide transport; transmembrane transport; ammonium transport

Disease: Rh-null, Regulator Type