RPN2 Antibody – Rabbit Polyclonal

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

RPN2: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Belongs to the SWP1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.4.99.18; Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis

Chromosomal Location of Human Ortholog: 20q12-q13.1

Cellular Component: endoplasmic reticulum membrane; membrane; rough endoplasmic reticulum; endoplasmic reticulum; oligosaccharyl transferase complex; integral to membrane; nucleus

Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; ribosome binding

Biological Process: response to drug; SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; protein modification process; protein amino acid N-linked glycosylation via asparagine; gene expression; post-translational protein modification; aging