Vanin 1 (VNN1) Antibody – Rabbit Polyclonal

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

VNN1: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily.

Protein type: Membrane protein, GPI anchor; EC 3.5.1.92; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Hydrolase; Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 6q23-q24

Cellular Component: plasma membrane; integral to membrane

Molecular Function: pantetheine hydrolase activity

Biological Process: positive regulation of T cell differentiation in the thymus; cell-cell adhesion; chronic inflammatory response; pantothenate metabolic process; innate immune response; response to oxidative stress; inflammatory response; cell motility; acute inflammatory response