ARF, P19 (ARF1) Antibody – Rabbit Polyclonal

ARF1: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. Belongs to the small GTPase superfamily. Arf family.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein; G protein, monomeric, ARF

Cellular Component: peroxisomal membrane; Golgi apparatus; neuron projection; focal adhesion; cell; endomembrane system; trans-Golgi network; cytosol; Golgi membrane; COPI-coated vesicle; postsynaptic membrane; sarcomere; membrane; cytoplasm; late endosome; plasma membrane; synapse; intracellular; cell junction

Molecular Function: protein binding; GDP binding; protein homodimerization activity; GTP binding; magnesium ion binding; nucleotide binding

Biological Process: positive regulation of catalytic activity; vesicle-mediated transport; Golgi to transport vesicle transport; positive regulation of calcium ion-dependent exocytosis; protein transport; cellular copper ion homeostasis; positive regulation of protein secretion; transport; regulation of receptor internalization; small GTPase mediated signal transduction; actin filament organization; positive regulation of endocytosis