Arrestin Beta 2 (ARRB2) Antibody – Goat Polyclonal

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

ARRB2: a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; endocytic vesicle; nucleus; plasma membrane

Molecular Function: angiotensin receptor binding; enzyme binding; G-protein-coupled receptor binding; protein binding; protein complex scaffold; receptor binding; ubiquitin protein ligase binding

Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of protein ubiquitination; platelet activation; positive regulation of protein ubiquitination; positive regulation of receptor internalization; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; receptor internalization; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway