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SSB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9202809

SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III -transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding… More details

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Product Overview

Online Datasheet in PDF
Product Name
SSB, Polyclonal Antibody
Full Product Name
SSB Antibody (N-term)
Product Gene Name
anti-SSB antibody
Product Synonym Names
Lupus La protein; La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B; SSB
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Bovine)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 2 (lot specific)
Specificity
This SSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-96 amino acids from the N-terminal region of human SSB.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SSB peptide (MBS9224837) is used for blocking the activity of SSB antibody (MBS9202809)
Molecular Weight
46837
Immunogen Sequence Positions
66-96
OMIM
109090
3D Structure
ModBase 3D Structure for P05455
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-SSB antibody

Immunology
Applications Tested/Suitable for anti-SSB antibody
ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB)
Application Notes for anti-SSB antibody
WB~~1:1000

Western Blot (WB) of anti-SSB antibody

Western blot analysis of anti-SSB Antibody (N-term) in 293 cell line lysates (35ug/lane).SSB(arrow) was detected using the purified Pab.
Rabbit Anti-SSB Polyclonal Antibody – Cat# MBS9202809

Immunohistochemistry (IHC) of anti-SSB antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SSB Antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-SSB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9202809

Flow Cytometry (FC/FACS) of anti-SSB antibody

SSB Antibody (N-term) flow cytometry analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-SSB Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9202809

Product References and Citations for anti-SSB antibody

Bitko,V., J. Virol. 82 (16), 7977-7987 (2008) Kotik-Kogan,O., Structure 16 (6), 852-862 (2008) Biswas,D., Clin. Rheumatol. 27 (6), 717-722 (2008)

Other Notes

Small volumes of anti-SSB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SSB purchase

MBS9202809 is an antibody targeting SSB. Also known as SSB Antibody (N-term). Reactive in Human (Predicted Reactivity: Bovine). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SSB. It may not necessarily be applicable to this product.

NCBI GI #
10835067
NCBI GeneID
6741
NCBI Accession #
NP_003133.1
UniProt Primary Accession #
P05455
UniProt Secondary Accession #
Q15367; Q53XJ4
UniProt Related Accession #
P05455
GenBank Nucleotide #
NM_003142.4
NCBI Official Full Name
lupus La protein
NCBI Official Synonym Full Names
Sjogren syndrome antigen B (autoantigen La)
NCBI Official Symbol
SSB
NCBI Official Synonym Symbols
La; LARP3; La/SSB
UniProt Protein Name
Lupus La protein
UniProt Synonym Protein Names
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
Protein Family
Heat shock protein
UniProt Gene Name
SSB
UniProt Synonym Gene Names
SS-B
UniProt Entry Name
LA_HUMAN
NCBI Protein Information
lupus La protein

NCBI Summary for SSB

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
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UniProt Comments for SSB

SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding

Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification
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Research Articles on SSB

1. expression of nuclear hLa Ag induces thymic clonal deletion and tTreg selection, and lymphocytic infiltration of the lung is a consequence of La-specific CD4(+) T cell autoimmunity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SSB antibody

 Products by Pathway  Pathway Diagram
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 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram

Diseases associated with anti-SSB antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >195 publications with SSB and Heart Diseases
 Death Antibodies  >94 publications with SSB and Death
 Vascular Diseases Antibodies  >94 publications with SSB and Vascular Diseases
 Inflammation Antibodies  >73 publications with SSB and Inflammation
 Kidney Diseases Antibodies  >52 publications with SSB and Kidney Diseases
 Lung Diseases Antibodies  >51 publications with SSB and Lung Diseases
 Weight Gain Antibodies  >40 publications with SSB and Weight Gain
 Necrosis Antibodies  >40 publications with SSB and Necrosis
 Fibrosis Antibodies  >39 publications with SSB and Fibrosis
 Pain Antibodies  >34 publications with SSB and Pain

Organs/Tissues associated with anti-SSB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >657 publications with SSB and Blood
 Heart Antibodies  >253 publications with SSB and Heart
 Skin Antibodies  >163 publications with SSB and Skin
 Salivary Gland Antibodies  >154 publications with SSB and Salivary Gland
 Liver Antibodies  >141 publications with SSB and Liver
 Connective Tissue Antibodies  >128 publications with SSB and Connective Tissue
 Mouth Antibodies  >119 publications with SSB and Mouth
 Lung Antibodies  >96 publications with SSB and Lung
 Muscle Antibodies  >84 publications with SSB and Muscle
 Brain Antibodies  >74 publications with SSB and Brain
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