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PPP2CB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6495367

MBS6495367 is an antibody targeting PPP2CB. Also known as PPP2CB (Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme, PP2Abeta, PP2A-beta, PP2CB, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) (AP). Reactive in Human, Mouse, Rat,… More details

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Product Overview

Online Datasheet in PDF
Product Name
PPP2CB, Polyclonal Antibody
Full Product Name
PPP2CB (Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme, PP2Abeta, PP2A-beta, PP2CB, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) (AP)
Product Gene Name
anti-PPP2CB antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human PP2A, B beta subunit. Minimal cross reactivity against PP2A, B gamma subunit. Species Crossreactivity: mouse, rat and bovine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
309
OMIM
176916
3D Structure
ModBase 3D Structure for P62714
Immunogen
Synthetic peptide peptide conjugated to KLH corresponding to the sequence NH2-Cys-Gly-Glu-Glu-Asp-Ile-Asp-THr-Arg-Lys-Ile-Asn-Asn-Ser-Phe-COOH.
Conjugate
AP
Positive Control
NIH/3T3 Cell Lysate
Note
Preservative Free

Product Categories/Family for anti-PPP2CB antibody

Antibodies; Enzymes; Phosphatase
Applications Tested/Suitable for anti-PPP2CB antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-PPP2CB antibody
IHC-P: 1:100
WB: 1:500
Applications are based on unconjugated antibody.

Immunohistochemistry (IHC) of anti-PPP2CB antibody

Immunohistochemistry: Representative image from a previous lot. PP2 staining on human testis, tissue pretreated with citrate buffer, pH 6.0. A previous lot of this antibody was diluted to 1:100, using IHC-Select detection with HRP-DAB.
Rabbit Anti-PPP2CB Polyclonal Antibody – Cat# MBS6495367

Western Blot (WB) of anti-PPP2CB antibody

Western Blot Analysis: NIH/3T3 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PP2A/B BETA (1:500 dilution of this lot). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates protein PP2A/B BETA (~55kD).
Rabbit Anti-PPP2CB Polyclonal Antibody, Western Blot (WB) – Cat# MBS6495367

Other Notes

Small volumes of anti-PPP2CB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP2CB. It may not necessarily be applicable to this product.

NCBI GI #
50402236
NCBI GeneID
5516
NCBI Accession #
P62714.1
UniProt Primary Accession #
P62714
UniProt Secondary Accession #
P11082; Q6FHK5; D3DSV4
UniProt Related Accession #
P62714
GenBank Nucleotide #
NM_001009552
NCBI Official Full Name
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
NCBI Official Synonym Full Names
protein phosphatase 2, catalytic subunit, beta isozyme
NCBI Official Symbol
PPP2CB
NCBI Official Synonym Symbols
PP2CB; PP2Abeta
UniProt Protein Name
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Protein Family
Serine/threonine-protein phosphatase
UniProt Gene Name
PPP2CB
UniProt Synonym Gene Names
PP2A-beta
UniProt Entry Name
PP2AB_HUMAN
NCBI Protein Information
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A-beta; protein phosphatase type 2A catalytic subunit; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2A catalytic subunit, beta isoform; protein phosp

NCBI Summary for PPP2CB

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
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UniProt Comments for PPP2CB

PPP2CB: one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: spindle pole; protein phosphatase type 2A complex; nucleus; cytosol; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: response to antibiotic; proteasomal ubiquitin-dependent protein catabolic process; apoptotic mitochondrial changes; fibroblast growth factor receptor signaling pathway; response to hydrogen peroxide; regulation of gene expression; negative regulation of Ras protein signal transduction; protein amino acid dephosphorylation
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Research Articles on PPP2CB

1. The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP2CB antibody

 Reference Product  PubMed Publications
 PPP2R2A antibody  >41 publications with PPP2CB and PPP2R2A
 PPP2R1A antibody  >35 publications with PPP2CB and PPP2R1A
 IGBP1 antibody  >20 publications with PPP2CB and IGBP1
 PPP2R5D antibody  >11 publications with PPP2CB and PPP2R5D
 TCP1 antibody  >1 publications with PPP2CB and TCP1

Pathways associated with anti-PPP2CB antibody

 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram

Diseases associated with anti-PPP2CB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >191 publications with PPP2CB and Nervous System Diseases
 Carcinoma Antibodies  >135 publications with PPP2CB and Carcinoma
 Cardiovascular Diseases Antibodies  >109 publications with PPP2CB and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >108 publications with PPP2CB and Disease Models, Animal
 Necrosis Antibodies  >75 publications with PPP2CB and Necrosis
 Heart Diseases Antibodies  >64 publications with PPP2CB and Heart Diseases
 Breast Neoplasms Antibodies  >60 publications with PPP2CB and Breast Neoplasms
 Inflammation Antibodies  >55 publications with PPP2CB and Inflammation
 Neoplasms, Experimental Antibodies  >53 publications with PPP2CB and Neoplasms, Experimental
 Liver Diseases Antibodies  >48 publications with PPP2CB and Liver Diseases

Organs/Tissues associated with anti-PPP2CB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >406 publications with PPP2CB and Brain
 Muscle Antibodies  >280 publications with PPP2CB and Muscle
 Blood Antibodies  >261 publications with PPP2CB and Blood
 Liver Antibodies  >175 publications with PPP2CB and Liver
 Heart Antibodies  >164 publications with PPP2CB and Heart
 Nerve Antibodies  >132 publications with PPP2CB and Nerve
 Lung Antibodies  >113 publications with PPP2CB and Lung
 Kidney Antibodies  >99 publications with PPP2CB and Kidney
 Vascular Antibodies  >96 publications with PPP2CB and Vascular
 Embryonic Tissue Antibodies  >44 publications with PPP2CB and Embryonic Tissue
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