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Calmodulin (CAM) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6466705

MBS6466705 is an antibody targeting CAM. Also known as Calmodulin, CT (CaM, CALM, CAM1, CAM) (Azide free) (HRP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Calmodulin (CAM), Polyclonal Antibody
Full Product Name
Calmodulin, CT (CaM, CALM, CAM1, CAM) (Azide free) (HRP)
Product Gene Name
anti-CAM antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human Calmodulin.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
16,838 Da
OMIM
114180
3D Structure
ModBase 3D Structure for P62158
Immunogen
Synthetic peptide selected from the C-terminal region of human Calmodulin (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-CAM antibody

Antibodies; Calmodulin
Applications Tested/Suitable for anti-CAM antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CAM antibody
WB: 1:100-1:500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CAM antibody

Western blot analysis of CALM1 Antibody (C-term) in Hela cell line lysates (35ug/lane). CALM1 (arrow) was detected using the purified Pab.(2ug/ml)
Rabbit Anti-CAM Polyclonal Antibody – Cat# MBS6466705

Flow Cytometry (FC/FACS) of anti-CAM antibody

CALM1 Antibody (C-term) flow cytometry analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CAM Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6466705

Immunohistochemistry (IHC) of anti-CAM antibody

CALM1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CALM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CAM Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6466705

Immunofluorescence (IF) of anti-CAM antibody

Confocal immunofluorescent analysis of CALM1 Antibody (C-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-CAM Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6466705

Product References and Citations for anti-CAM antibody

1. Zhao, D., et.al., Zhonghua Yi Xue Za Zhi 88(35), 2452-2456 (2008). 2. Martins-de-Souza, D., et.al., J. Neural Transm. 116(3), 275-289 (2009).

Other Notes

Small volumes of anti-CAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CAM. It may not necessarily be applicable to this product.

NCBI GI #
5901912
NCBI GeneID
801
NCBI Accession #
NP_008819
UniProt Primary Accession #
P62158
UniProt Secondary Accession #
P02593; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3
UniProt Related Accession #
P62158
GenBank Nucleotide #
NM_006888
NCBI Official Full Name
calmodulin
NCBI Official Synonym Full Names
calmodulin 1 (phosphorylase kinase, delta)
NCBI Official Symbol
CALM1
NCBI Official Synonym Symbols
caM; CAMI; PHKD; CPVT4; DD132; CALML2
UniProt Protein Name
Calmodulin
Protein Family
Calmodulin
UniProt Gene Name
CALM1
UniProt Synonym Gene Names
CALM; CAM; CAM1; CaM
UniProt Entry Name
CALM_HUMAN
NCBI Protein Information
calmodulin; phosphorylase kinase, delta subunit; prepro-calmodulin 1

UniProt Comments for CAM

Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 14q32.11

Cellular Component: nucleoplasm; spindle pole; centrosome; sarcomere; growth cone; spindle microtubule; cytoplasm; plasma membrane; extracellular region; cytosol; nucleus; vesicle

Molecular Function: protein domain specific binding; nitric-oxide synthase regulator activity; titin binding; calcium ion binding; calcium-dependent protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein binding; N-terminal myristoylation domain binding; phospholipase binding; thioesterase binding; type 3 metabotropic glutamate receptor binding; phosphoinositide 3-kinase binding; nitric-oxide synthase binding; adenylate cyclase binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; phototransduction, visible light; inositol phosphate metabolic process; nerve growth factor receptor signaling pathway; pathogenesis; signal transduction; nitric oxide metabolic process; positive regulation of protein amino acid dephosphorylation; synaptic transmission; substantia nigra development; platelet degranulation; muscle contraction; positive regulation of cyclic nucleotide metabolic process; response to corticosterone stimulus; epidermal growth factor receptor signaling pathway; mitochondrion organization and biogenesis; platelet activation; fibroblast growth factor receptor signaling pathway; glycogen catabolic process; regulation of heart rate; positive regulation of nitric-oxide synthase activity; organelle organization and biogenesis; adenylate cyclase activation; response to amphetamine; glucose metabolic process; positive regulation of protein amino acid autophosphorylation; regulation of cytokinesis; rhodopsin mediated signaling; G-protein coupled receptor protein signaling pathway; regulation of rhodopsin mediated signaling; phospholipase C activation; carbohydrate metabolic process; innate immune response; positive regulation of cyclic-nucleotide phosphodiesterase activity; detection of calcium ion; regulation of nitric-oxide synthase activity; blood coagulation; response to calcium ion; vascular endothelial growth factor receptor signaling pathway

Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CAM antibody

 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of CaMK IV Pathway antibodies  Activation Of CaMK IV Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram

Diseases associated with anti-CAM antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >7 publications with CAM and Cardiovascular Diseases
 Drug Toxicity Antibodies  >3 publications with CAM and Drug Toxicity
 Fibrosis Antibodies  >3 publications with CAM and Fibrosis
 Neoplasms Antibodies  >3 publications with CAM and Neoplasms
 Brain Diseases Antibodies  >2 publications with CAM and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with CAM and Disease Models, Animal
 Atrophy Antibodies  >1 publications with CAM and Atrophy
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with CAM and Prenatal Exposure Delayed Effects
 Phencyclidine Abuse Antibodies  >1 publications with CAM and Phencyclidine Abuse
 Marijuana Abuse Antibodies  >1 publications with CAM and Marijuana Abuse

Organs/Tissues associated with anti-CAM antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >9 publications with CAM and Muscle
 Heart Antibodies  >7 publications with CAM and Heart
 Bone Antibodies  >6 publications with CAM and Bone
 Blood Antibodies  >5 publications with CAM and Blood
 Brain Antibodies  >5 publications with CAM and Brain
 Nerve Antibodies  >2 publications with CAM and Nerve
 Parathyroid Antibodies  >1 publications with CAM and Parathyroid
 Pancreas Antibodies  >1 publications with CAM and Pancreas
 Embryonic Tissue Antibodies  >1 publications with CAM and Embryonic Tissue
 Intestine Antibodies  >1 publications with CAM and Intestine
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