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Cadherin-13 (CDH13) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6466484

MBS6466484 is an antibody targeting CDH13. Also known as Cadherin-13, CT (Cadherin, H, Truncated Cadherin, T-cadherin, T-cad, Heart Cadherin, H-cadherin, P105, CDH13, CDHH) (FITC). Reactive in Human. Host: Rabbit. More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Cadherin-13 (CDH13), Polyclonal Antibody
Full Product Name
Cadherin-13, CT (Cadherin, H, Truncated Cadherin, T-cadherin, T-cad, Heart Cadherin, H-cadherin, P105, CDH13, CDHH) (FITC)
Product Gene Name
anti-CDH13 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human CDH13.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
Predicted: 78; 84 kDa

Observed: 85 kDa
OMIM
601364
3D Structure
ModBase 3D Structure for P55290
Immunogen
Synthetic peptide selected from the C-terminal region of human CDH13 (KLH).
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CDH13 antibody

Antibodies; Cadherin
Applications Tested/Suitable for anti-CDH13 antibody
FLISA, Western Blot (WB), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)
Application Notes for anti-CDH13 antibody
FLISA: 1:1,000
WB: 1:50-1:100
FC/FACS: 1:10-1:50
IHC: 1:10-1:50
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CDH13 antibody

Western blot analysis of CDH13 (arrow) using rabbit polyclonal CDH13 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDH13 gene (Lane 2) (Origene Technologies).
Rabbit Anti-CDH13 Polyclonal Antibody – Cat# MBS6466484

Immunohistochemistry (IHC) of anti-CDH13 antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CDH13 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CDH13 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6466484

Flow Cytometry (FC/FACS) of anti-CDH13 antibody

Flow cytometric analysis of MCF-7 cells using H Cadherin (CDH13) Antibody (C-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CDH13 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6466484

Product References and Citations for anti-CDH13 antibody

1. Qian, Z.R., Mod. Pathol. 20(12), 1269-1277 (2007). 2. Tsou, J.A., Mol. Cancer 6, 70 (2007).

Other Notes

Small volumes of anti-CDH13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH13. It may not necessarily be applicable to this product.

NCBI GI #
166197701
NCBI GeneID
956
NCBI Accession #
NP_001248
UniProt Primary Accession #
P55290
UniProt Secondary Accession #
O60495; Q8N6K2; B2R8D0; G5E9N0
UniProt Related Accession #
O75355
GenBank Nucleotide #
NM_001248.2
NCBI Official Full Name
Homo sapiens ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3), mRNA
NCBI Official Synonym Full Names
ectonucleoside triphosphate diphosphohydrolase 3
NCBI Official Symbol
ENTPD3
NCBI Official Synonym Symbols
HB6; CD39L3; NTPDase-3
UniProt Protein Name
Cadherin-13
UniProt Synonym Protein Names
Heart cadherin; H-cadherin; P105; Truncated cadherin; T-cad; T-cadherin
Protein Family
Cadherin
UniProt Gene Name
CDH13
UniProt Synonym Gene Names
CDHH; H-cadherin; T-cad; T-cadherin
UniProt Entry Name
CAD13_HUMAN
NCBI Protein Information
ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3; ecto-ATPase 3; ecto-ATPDase 3; ecto-apyrase 3; CD39 antigen-like 3; ecto-ATP diphosphohydrolase 3

NCBI Summary for CDH13

This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

UniProt Comments for CDH13

CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 16q23.3

Cellular Component: extracellular space; neuron projection; focal adhesion; cytoplasm; plasma membrane; caveola; external side of plasma membrane

Molecular Function: adiponectin binding; protein homodimerization activity; cadherin binding; low-density lipoprotein binding; calcium ion binding

Biological Process: lamellipodium biogenesis; intercellular junction assembly and maintenance; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; Rac protein signal transduction; positive regulation of calcium-mediated signaling; negative regulation of cell adhesion; keratinocyte proliferation; Rho protein signal transduction; regulation of epidermal growth factor receptor signaling pathway; low density lipoprotein mediated signaling; negative regulation of cell proliferation; localization within membrane; calcium-dependent cell-cell adhesion; regulation of endocytosis; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; sprouting angiogenesis; positive regulation of cell-matrix adhesion; homophilic cell adhesion; positive regulation of cell migration
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Research Articles on CDH13

1. NTPDase3 is the major ectonucleotidase in pancreatic beta-cells in multiple species and modulates insulin secretion by controlling activation of purinergic receptors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDH13 antibody

 Reference Product  PubMed Publications
 ENTPD2 antibody  >2 publications with CDH13 and ENTPD2
 ENTPD6 antibody  >1 publications with CDH13 and ENTPD6
 NT5E antibody  >1 publications with CDH13 and NT5E
 ENTPD5 antibody  >1 publications with CDH13 and ENTPD5

Pathways associated with anti-CDH13 antibody

 Products by Pathway  Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
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 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-CDH13 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with CDH13 and Inflammation

Organs/Tissues associated with anti-CDH13 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with CDH13 and Nerve
 Liver Antibodies  >1 publications with CDH13 and Liver
 Kidney Antibodies  >1 publications with CDH13 and Kidney
 Pancreas Antibodies  >1 publications with CDH13 and Pancreas
 Brain Antibodies  >1 publications with CDH13 and Brain
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