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POLE2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9212924

MBS9212924 is an antibody targeting POLE2. Also known as POLE2 Antibody (C-term). Reactive in Human (Predicted Reactivity: Chicken). Host: Rabbit. Participates in DNA repair and in chromosomal DNA replication. More details

$240 / 0.08 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
POLE2, Polyclonal Antibody
Full Product Name
POLE2 Antibody (C-term)
Product Gene Name
anti-POLE2 antibody
Product Synonym Names
DNA polymerase epsilon subunit 2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B; POLE2; DPE2
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Chicken)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This POLE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human POLE2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
POLE2 peptide (MBS9229038) is used for blocking the activity of POLE2 antibody (MBS9212924)
Molecular Weight
59537
Immunogen Sequence Positions
495-523
OMIM
602670
3D Structure
ModBase 3D Structure for P56282
Antigen Type
Synthetic Peptide
Applications Tested/Suitable for anti-POLE2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-POLE2 antibody
WB~~1:1000

Western Blot (WB) of anti-POLE2 antibody

POLE2 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the POLE2 antibody detected the POLE2 protein (arrow).
Rabbit Anti-POLE2 Polyclonal Antibody – Cat# MBS9212924

Other Notes

Small volumes of anti-POLE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for POLE2. It may not necessarily be applicable to this product.

NCBI GI #
309747079
NCBI GeneID
5427
NCBI Accession #
NP_001184259.1
NCBI Related Accession #
NP_001184260.1; NP_002683.2
UniProt Primary Accession #
P56282
UniProt Secondary Accession #
O43560; A0AV55; A4FU92; A4LBB7; A6NH58; B4DDE6
UniProt Related Accession #
P56282
GenBank Nucleotide #
NM_001197330.1
NCBI Official Full Name
DNA polymerase epsilon subunit 2 isoform 2
NCBI Official Synonym Full Names
polymerase (DNA directed), epsilon 2, accessory subunit
NCBI Official Symbol
POLE2
NCBI Official Synonym Symbols
DPE2
UniProt Protein Name
DNA polymerase epsilon subunit 2
UniProt Synonym Protein Names
DNA polymerase II subunit 2; DNA polymerase epsilon subunit B
Protein Family
DNA polymerase
UniProt Gene Name
POLE2
UniProt Synonym Gene Names
DPE2
UniProt Entry Name
DPOE2_HUMAN
NCBI Protein Information
DNA polymerase epsilon subunit 2

UniProt Comments for POLE2

POLE2: Participates in DNA repair and in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; EC 2.7.7.7; DNA replication; DNA repair, damage; Nucleotide Metabolism - purine; Transferase

Chromosomal Location of Human Ortholog: 14q21-q22

Cellular Component: nucleoplasm; epsilon DNA polymerase complex; intracellular membrane-bound organelle

Molecular Function: DNA binding; DNA-directed DNA polymerase activity

Biological Process: telomere maintenance via semi-conservative replication; DNA replication initiation; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; error-prone postreplication DNA repair; telomere maintenance via recombination; mitotic cell cycle; nucleotide-excision repair, DNA gap filling; DNA repair; DNA-dependent DNA replication; DNA replication; telomere maintenance; G1/S transition of mitotic cell cycle
Show more

Research Articles on POLE2

1. found that mutations occurred in POLE2 in 5 out of 16 cases of human colon cancer examined.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-POLE2 antibody

 Reference Product  PubMed Publications
 POLA2 antibody  >1 publications with POLE2 and POLA2
 POLA1 antibody  >1 publications with POLE2 and POLA1
 POLE4 antibody  >1 publications with POLE2 and POLE4
 POLE3 antibody  >1 publications with POLE2 and POLE3
 POLE antibody  >1 publications with POLE2 and POLE

Pathways associated with anti-POLE2 antibody

 Products by Pathway  Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
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 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
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 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram

Diseases associated with anti-POLE2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with POLE2 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with POLE2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >1 publications with POLE2 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with POLE2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-POLE2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with POLE2 and Bone
 Bladder Antibodies  >1 publications with POLE2 and Bladder
 Liver Antibodies  >1 publications with POLE2 and Liver
 Bone Marrow Antibodies  >1 publications with POLE2 and Bone Marrow
 Brain Antibodies  >1 publications with POLE2 and Brain
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