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CLIP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9205387

CLIP1 may be a intermediate filament associated protein that links endocytic vesicles to microtubules. More details

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Product Overview

Online Datasheet in PDF
Product Name
CLIP1, Polyclonal Antibody
Full Product Name
CLIP1 Antibody (N-term)
Product Gene Name
anti-CLIP1 antibody
Product Synonym Names
CAP-Gly domain-containing linker protein 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin; CLIP1; CYLN1; RSN
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse (Predicted Reactivity: Chicken, Rat)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.36 (lot specific)
Specificity
This CLIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-254 amino acids from the N-terminal region of human CLIP1.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CLIP1 peptide (MBS9227941) is used for blocking the activity of CLIP1 antibody (MBS9205387)
Molecular Weight
162246
Immunogen Sequence Positions
228-254
OMIM
179838
3D Structure
ModBase 3D Structure for P30622
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-CLIP1 antibody

Cancer; Cell Biology; Signal transduction
Applications Tested/Suitable for anti-CLIP1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-CLIP1 antibody
WB~~1:1000

Western Blot (WB) of anti-CLIP1 antibody

Western blot analysis of CLIP1 Antibody (N-term) in Hela cell line lysates (35ug/lane). CLIP1 (arrow) was detected using the purified Pab.
Rabbit Anti-CLIP1 Polyclonal Antibody – Cat# MBS9205387

Western Blot (WB) of anti-CLIP1 antibody

Western blot analysis of CLIP1 Antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). CLIP1 (arrow) was detected using the purified Pab.
Rabbit Anti-CLIP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9205387

Immunohistochemistry (IHC) of anti-CLIP1 antibody

CLIP1 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLIP1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CLIP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9205387

Flow Cytometry (FC/FACS) of anti-CLIP1 antibody

CLIP1 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CLIP1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9205387

Product References and Citations for anti-CLIP1 antibody

Yang,X., et.al., J. Biol. Chem. 284 (42), 28775-28782 (2009)
Meunier,B., et.al., Eur. J. Cell Biol. 88 (2), 91-102 (2009)

Other Notes

Small volumes of anti-CLIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLIP1 purchase

MBS9205387 is an antibody targeting CLIP1. Also known as CLIP1 Antibody (N-term). Reactive in Human, mouse (Predicted Reactivity: Chicken, Rat). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLIP1. It may not necessarily be applicable to this product.

NCBI GI #
351542242
NCBI GeneID
6249
NCBI Accession #
NP_001234926.1
NCBI Related Accession #
NP_002947.1; NP_937883.1
UniProt Primary Accession #
P30622
UniProt Secondary Accession #
Q17RS4; Q29RG0; A0AVD3
UniProt Related Accession #
P30622
GenBank Nucleotide #
NM_001247997.1
NCBI Official Full Name
CAP-Gly domain-containing linker protein 1 isoform c
NCBI Official Synonym Full Names
CAP-GLY domain containing linker protein 1
NCBI Official Symbol
CLIP1
NCBI Official Synonym Symbols
RSN; CLIP; CYLN1; CLIP170; CLIP-170
UniProt Protein Name
CAP-Gly domain-containing linker protein 1
UniProt Synonym Protein Names
Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin
Protein Family
CAP-Gly domain-containing linker protein
UniProt Gene Name
CLIP1
UniProt Synonym Gene Names
CYLN1; RSN; CLIP-170
UniProt Entry Name
CLIP1_HUMAN
NCBI Protein Information
CAP-Gly domain-containing linker protein 1

NCBI Summary for CLIP1

The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for CLIP1

Restin: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3. Detected in dendritic cells. Highly expressed in the Reed-Sternberg cells of Hodgkin disease. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q24.3

Cellular Component: microtubule cytoskeleton; kinetochore; ruffle; microtubule; centrosome; cytoplasmic vesicle membrane; cytoplasmic microtubule; cytoplasm; intermediate filament; cytosol; endosome

Molecular Function: tubulin binding; microtubule plus-end binding; protein binding; protein homodimerization activity; nucleic acid binding; zinc ion binding; metal ion binding; microtubule binding

Biological Process: mitosis; positive regulation of microtubule polymerization; mitotic cell cycle; microtubule bundle formation
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Research Articles on CLIP1

1. Data suggest that CLIP-170 acts as a novel recruiter and spatial regulator of PLK1 at kinetochores during early mitosis, promoting K-fiber stability and chromosome alignment for error-free chromosome segregation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLIP1 antibody

 Reference Product  PubMed Publications
 CLASP1 antibody  >1 publications with CLIP1 and CLASP1
 DCTN1 antibody  >1 publications with CLIP1 and DCTN1

Pathways associated with anti-CLIP1 antibody

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Diseases associated with anti-CLIP1 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >1 publications with CLIP1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CLIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with CLIP1 and Skin
 Liver Antibodies  >1 publications with CLIP1 and Liver
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