• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

COP9 Signalosome Complex Subunit 7a (COPS7A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7002280

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COP9 signalosome complex subunit 7a (COPS7A), Polyclonal Antibody
Full Product Name
Rabbit anti-human COP9 signalosome complex subunit 7a polyclonal Antibody
Product Gene Name
anti-COPS7A antibody
Product Synonym Names
SGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a; COPS7A; CSN7A; DERP10
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Liquid
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
Matching Pairs
Unconjugated Antibody: COPS7A (MBS7002280)
HRP Conjugated Antibody: COP9 (MBS1491731)
Matching Pairs
Unconjugated Antibody: COPS7A (MBS7002280)
Biotin Conjugated Antibody: COP9 (MBS1494812)
Show more
Molecular Weight
30,277 Da
OMIM
616009
3D Structure
ModBase 3D Structure for Q9UBW8
Immunogen
Recombinant human COP9 signalosome complex subunit 7a protein (2-275aa)
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47971 / sc-47968
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-COPS7A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-COPS7A antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-COPS7A antibody

Western blot
All lanes: COP9 signalosome complex subunit 7a antibody at 2ug/ml+mouse brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 30kDa
Observed band size: 30kDa
Rabbit Anti-COPS7A Polyclonal Antibody – Cat# MBS7002280

Immunohistochemistry (IHC) of anti-COPS7A antibody

Immunohistochemistry of paraffin-embedded human adrenal gland using MBS7002280 at dilution 1:100
Rabbit Anti-COPS7A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7002280

Immunohistochemistry (IHC) of anti-COPS7A antibody

Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7002280 at dilution 1:100
Rabbit Anti-COPS7A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS7002280

Other Notes

Small volumes of anti-COPS7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPS7A purchase

MBS7002280 is an antibody targeting COPS7A. Also known as Rabbit anti-human COP9 signalosome complex subunit 7a polyclonal Antibody. Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COPS7A. It may not necessarily be applicable to this product.

NCBI GI #
255760064
NCBI GeneID
50813
NCBI Accession #
NP_001157565.1
UniProt Primary Accession #
Q9UBW8
UniProt Secondary Accession #
Q9NVX3; Q9UJW4; A8K9A6
UniProt Related Accession #
Q9UBW8
GenBank Nucleotide #
NM_001164093.1
NCBI Official Full Name
COP9 signalosome complex subunit 7a
NCBI Official Synonym Full Names
COP9 signalosome subunit 7A
NCBI Official Symbol
COPS7A
NCBI Official Synonym Symbols
CSN7; CSN7A; SGN7a
UniProt Protein Name
COP9 signalosome complex subunit 7a
UniProt Synonym Protein Names
Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a
Protein Family
COP9 signalosome complex
UniProt Gene Name
COPS7A
UniProt Synonym Gene Names
CSN7A; DERP10; SGN7a; Signalosome subunit 7a
UniProt Entry Name
CSN7A_HUMAN
NCBI Protein Information
COP9 signalosome complex subunit 7a

NCBI Summary for COPS7A

This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

UniProt Comments for COPS7A

COPS7A: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: cytoplasm; nucleoplasm; signalosome

Molecular Function: protein binding

Biological Process: cullin deneddylation; DNA repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; transcription-coupled nucleotide-excision repair
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COPS7A antibody

 Reference Product  PubMed Publications
 COPS5 antibody  >1 publications with COPS7A and COPS5

Pathways associated with anti-COPS7A antibody

 Products by Pathway  Pathway Diagram
 DNA Damage Recognition In GG-NER Pathway antibodies  DNA Damage Recognition In GG-NER Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Formation Of TC-NER Pre-Incision Complex Pathway antibodies  Formation Of TC-NER Pre-Incision Complex Pathway Diagram
 Global Genome Nucleotide Excision Repair (GG-NER) Pathway antibodies  Global Genome Nucleotide Excision Repair (GG-NER) Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway antibodies  Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway Diagram
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000