DGK Beta (DGKbeta) Antibody – Rabbit Polyclonal

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

DGKB: is a cytoplasmic enzyme that phosphorylates 1,2-diacylglycerol. A regulator of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD).

Protein type: Lipid Metabolism - glycerophospholipid; Kinase, lipid; Lipid Metabolism - glycerolipid; Motility/polarity/chemotaxis; EC 2.7.1.107

Chromosomal Location of Human Ortholog: 7p21.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: calcium ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: platelet activation; protein kinase C activation; blood coagulation; phosphorylation