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NPY2R Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420568

MBS420568 is an antibody targeting Npy2r. Also known as Goat anti-Npy2r (mouse) Antibody. Reactive in Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Npy2r, Polyclonal Antibody
Full Product Name
Goat anti-Npy2r (mouse) Antibody
Product Gene Name
anti-Npy2r antibody
Product Synonym Names
NPY2R; neuropeptide Y receptor Y2; MGC124241; MGC124242; MGC124244; NPY-Y2 receptor; NPY2-R
Immunogen Sequence
KAKKNLEVKK NN
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Npy2r peptide (MBS426410) is used for blocking the activity of Npy2r antibody (MBS420568)
Molecular Weight
42,628 Da
Immunogen
Peptide with sequence C-KAKKNLEVKKNN, from the internal region of the protein sequence according to NP_032757.1.
Note
Pease note this antibody was designed using the Mouse sequence NP_032757.1, which differs by 1 amino acid from the Human sequence NP_000901.1.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Npy2r antibody
Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-Npy2r antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 40+45kDa bands observed in Rat Brain lysates (calculated MW of 42.6kDa according to NP032757.1). Recommended concentration: 0.1-0.3ug/ml.
Immunoprecipitation: A customer successfully used this product for IP of Human Y2R, but the Human Y2R could not be detected in WB by this antibody.

Western Blot (WB) of anti-Npy2r antibody

(0.1ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-NPY2R Polyclonal Antibody – Cat# MBS420568

Other Notes

Small volumes of anti-Npy2r antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Npy2r. It may not necessarily be applicable to this product.

NCBI GI #
6679122
NCBI GeneID
4887
NCBI Accession #
NP_032757.1
UniProt Secondary Accession #
Q8BWV1; F7C6W7
UniProt Related Accession #
P97295
GenBank Nucleotide #
NM_008731.2
NCBI Official Full Name
neuropeptide Y receptor Y2
NCBI Official Synonym Full Names
neuropeptide Y receptor Y2
NCBI Official Symbol
Npy2r
NCBI Official Synonym Symbols
NPY2-R
UniProt Protein Name
Neuropeptide Y receptor type 2
UniProt Synonym Protein Names
NPY-Y2 receptor; Y2 receptor
Protein Family
Neuropeptide Y receptor
UniProt Gene Name
Npy2r
UniProt Synonym Gene Names
NPY2-R; Y2 receptor
UniProt Entry Name
NPY2R_MOUSE
NCBI Protein Information
neuropeptide Y receptor type 2

UniProt Comments for Npy2r

NPY2R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Cellular Component: cytosol; integral to membrane; integral to plasma membrane; membrane; nonmotile primary cilium; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide Y receptor activity; peptide YY receptor activity; signal transducer activity

Biological Process: behavioral fear response; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; negative regulation of neurological process; negative regulation of secretion; negative regulation of synaptic transmission; negative regulation of synaptic transmission, glutamatergic; nitric oxide mediated signal transduction; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; secretion; signal transduction; synaptic transmission
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Research Articles on Npy2r

1. Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Npy2r antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Non-odorant GPCRs Pathway antibodies  Non-odorant GPCRs Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-Npy2r antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with Npy2r and Brain Diseases
 Abnormalities, Multiple Antibodies  >2 publications with Npy2r and Abnormalities, Multiple
 Alcoholism Antibodies  >2 publications with Npy2r and Alcoholism
 Hypertension Antibodies  >2 publications with Npy2r and Hypertension
 Cognition Disorders Antibodies  >1 publications with Npy2r and Cognition Disorders
 Inflammation Antibodies  >1 publications with Npy2r and Inflammation
 Hypertrophy Antibodies  >1 publications with Npy2r and Hypertrophy
 Cardiomegaly Antibodies  >1 publications with Npy2r and Cardiomegaly
 Neurobehavioral Manifestations Antibodies  >1 publications with Npy2r and Neurobehavioral Manifestations
 Epilepsy Antibodies  >1 publications with Npy2r and Epilepsy

Organs/Tissues associated with anti-Npy2r antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with Npy2r and Brain
 Intestine Antibodies  >2 publications with Npy2r and Intestine
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