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PTGER2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS240882

Prostaglandin E Receptor EP2 is a member of the Prostanoid Receptor subfamily. Along with several other receptor subtypes (EP1, EP3, and EP4), it mediates the diverse biological effects of Prostaglandin E2 (PGE2). PGE2 has been implicated in numerous… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PTGER2 / EP2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PTGER2 / EP2
Product Gene Name
anti-PTGER2 antibody
Product Synonym Gene Name
EP2
Product Synonym Names
Anti-PTGER2 / EP2 Antibody (C-Terminus) IHC-plus; PTGER2; EP2 prostaglandin e2 receptor; EP2 prostaglandin receptor; EP2; Pge2-r ep2; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2; Prostanoid EP2 receptor; EP2 receptor; PGE receptor EP2 subtype; Human PTGER2; EP2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human EP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
39,761 Da
OMIM
176804
3D Structure
ModBase 3D Structure for P43116
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human EP2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Bovine (88%); Mouse, Bat, Dog, Panda, Pig (81%).
Immunogen Type
Synthetic peptide
Immunogen
PTGER2 / EP2 antibody was raised against synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human EP2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Bovine (88%); Mouse, Bat, Dog, Panda, Pig (81%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-PTGER2 antibody

Family: GPCR; Subfamily: Prostanoid
Applications Tested/Suitable for anti-PTGER2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-PTGER2 antibody
ELISA, IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PTGER2 antibody

Anti-EP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-PTGER2 Polyclonal Antibody – Cat# MBS240882

Other Notes

Small volumes of anti-PTGER2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGER2 purchase

MBS240882 is an antibody targeting PTGER2. Also known as Rabbit Polyclonal to Human PTGER2 / EP2. Reactive in Gibbon, Gorilla, Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGER2. It may not necessarily be applicable to this product.

NCBI GI #
31881630
NCBI GeneID
5732
NCBI Accession #
NP_000947.2
UniProt Primary Accession #
P43116
UniProt Secondary Accession #
Q52LG8; D3DSC0
UniProt Related Accession #
P43116
GenBank Nucleotide #
NM_000956.3
NCBI Official Full Name
prostaglandin E2 receptor EP2 subtype
NCBI Official Synonym Full Names
prostaglandin E receptor 2 (subtype EP2), 53kDa
NCBI Official Symbol
PTGER2
NCBI Official Synonym Symbols
EP2
UniProt Protein Name
Prostaglandin E2 receptor EP2 subtype
UniProt Synonym Protein Names
Prostanoid EP2 receptor
Protein Family
Prostaglandin E2 receptor
UniProt Gene Name
PTGER2
UniProt Synonym Gene Names
PGE receptor EP2 subtype; PGE2 receptor EP2 subtype
UniProt Entry Name
PE2R2_HUMAN
NCBI Protein Information
prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (subtype EP2), 53kD

NCBI Summary for PTGER2

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

UniProt Comments for PTGER2

PTGER2: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide; G-protein signaling, adenylate cyclase activating pathway; regulation of cell proliferation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance
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Research Articles on PTGER2

1. Overexpression of EP2 was more observed in esophageal squamous cell carcinoma than in the control group. Overexpression of EP2 ESCC tissues might play an important role in carcinogenesis and the progression of ESCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTGER2 antibody

 Reference Product  PubMed Publications
 PTGER4 antibody  >208 publications with PTGER2 and PTGER4
 PTGIR antibody  >10 publications with PTGER2 and PTGIR
 PTH antibody  >4 publications with PTGER2 and PTH
 ADRB2 antibody  >2 publications with PTGER2 and ADRB2
 POMC antibody  >1 publications with PTGER2 and POMC
 CRH antibody  >1 publications with PTGER2 and CRH

Pathways associated with anti-PTGER2 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram

Diseases associated with anti-PTGER2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >67 publications with PTGER2 and Inflammation
 Necrosis Antibodies  >38 publications with PTGER2 and Necrosis
 Nervous System Diseases Antibodies  >23 publications with PTGER2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >22 publications with PTGER2 and Cardiovascular Diseases
 Immune System Diseases Antibodies  >21 publications with PTGER2 and Immune System Diseases
 Lung Neoplasms Antibodies  >12 publications with PTGER2 and Lung Neoplasms
 Adenocarcinoma Antibodies  >11 publications with PTGER2 and Adenocarcinoma
 Kidney Diseases Antibodies  >7 publications with PTGER2 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >6 publications with PTGER2 and Neoplasms, Experimental
 Uterine Diseases Antibodies  >6 publications with PTGER2 and Uterine Diseases

Organs/Tissues associated with anti-PTGER2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >108 publications with PTGER2 and Blood
 Lung Antibodies  >46 publications with PTGER2 and Lung
 Uterus Antibodies  >40 publications with PTGER2 and Uterus
 Kidney Antibodies  >30 publications with PTGER2 and Kidney
 Eye Antibodies  >21 publications with PTGER2 and Eye
 Bone Marrow Antibodies  >15 publications with PTGER2 and Bone Marrow
 Connective Tissue Antibodies  >9 publications with PTGER2 and Connective Tissue
 Liver Antibodies  >9 publications with PTGER2 and Liver
 Ascites Antibodies  >2 publications with PTGER2 and Ascites
 Adipose Tissue Antibodies  >1 publications with PTGER2 and Adipose Tissue
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