Gelsolin (GS) Antibody – Rabbit Polyclonal

Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2 B|2 23.5 cM

Cellular Component: actin cap; actin cytoskeleton; blood microparticle; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; extracellular exosome; extracellular region; extracellular space; focal adhesion; lamellipodium; myelin sheath; nucleus; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; podosome; protein complex; ruffle; sarcoplasm

Molecular Function: actin binding; actin filament binding; calcium ion binding; metal ion binding; myosin II binding; protein binding

Biological Process: actin filament capping; actin filament polymerization; actin filament reorganization; actin filament severing; actin nucleation; actin polymerization or depolymerization; amyloid fibril formation; apoptosis; barbed-end actin filament capping; cell projection organization; cellular response to cadmium ion; cellular response to interferon-gamma; negative regulation of virion penetration into host cell; phagocytosis, engulfment; phosphoinositide-mediated signaling; positive regulation of actin nucleation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of gene expression; positive regulation of keratinocyte apoptotic process; positive regulation of protein processing in phagocytic vesicle; protein destabilization; regulation of cell adhesion; regulation of establishment of T cell polarity; regulation of plasma membrane raft polarization; regulation of podosome assembly; regulation of receptor clustering; sequestering of actin monomers; striated muscle atrophy; vesicle-mediated transport