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YMEL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6364333

YMEL1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
YMEL1, Polyclonal Antibody
Full Product Name
YMEL1, NT (YME1L1, FTSH1, YME1L, ATP-dependent zinc metalloprotease YME1L1, ATP-dependent metalloprotease FtsH1, Meg-4, Presenilin-associated metalloprotease, YME1-like protein 1) (MaxLight 650)
Product Gene Name
anti-YMEL1 antibody
Product Synonym Gene Name
YME1L1
Product Synonym Names
YME1L1; FTSH1; YME1L; ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease FtsH1; Meg-4; Presenilin-associated metalloprotease; YME1-like protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Hamster, Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
75,982 Da
OMIM
607472
3D Structure
ModBase 3D Structure for Q96TA2
Immunogen
YMEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 140-170 from the N-terminal region of human YMEL1.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-YMEL1 antibody

Antibodies; Enzymes
Applications Tested/Suitable for anti-YMEL1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-YMEL1 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-YMEL1 antibody

Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006). Deloukas, P., et al. Nature 429(6990):375-381(2004). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003).

Other Notes

Small volumes of anti-YMEL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YMEL1 purchase

MBS6364333 is an antibody targeting YMEL1. Also known as YMEL1, NT (YME1L1, FTSH1, YME1L, ATP-dependent zinc metalloprotease YME1L1, ATP-dependent metalloprotease FtsH1, Meg-4, Presenilin-associated metalloprotease, YME1-like protein 1) (MaxLight 650). Reactive in Hamster, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for YMEL1. It may not necessarily be applicable to this product.

NCBI GI #
46397258
NCBI GeneID
10730
NCBI Accession #
Q96TA2.2
UniProt Primary Accession #
Q96TA2
UniProt Secondary Accession #
Q5T8D9; Q9H1Q0; Q9UMR9; B4DNM1; D3DRV8; D3DRV9
UniProt Related Accession #
Q96TA2
NCBI Official Full Name
ATP-dependent zinc metalloprotease YME1L1
NCBI Official Synonym Full Names
YME1 like 1 ATPase
NCBI Official Symbol
YME1L1
NCBI Official Synonym Symbols
FTSH; MEG4; PAMP; YME1L
UniProt Protein Name
ATP-dependent zinc metalloprotease YME1L1
UniProt Synonym Protein Names
ATP-dependent metalloprotease FtsH1; Meg-4; Presenilin-associated metalloprotease; PAMP; YME1-like protein 1
UniProt Gene Name
YME1L1
UniProt Synonym Gene Names
FTSH1; YME1L; PAMP
UniProt Entry Name
YMEL1_HUMAN
NCBI Protein Information
ATP-dependent zinc metalloprotease YME1L1

NCBI Summary for YMEL1

The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for YMEL1

YME1L1: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Protease; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: integral to membrane; membrane; mitochondrial inner membrane; mitochondrion; nucleoplasm

Molecular Function: ATP binding; ATP-dependent peptidase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity

Biological Process: cell proliferation; misfolded or incompletely synthesized protein catabolic process; mitochondrion organization and biogenesis
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Research Articles on YMEL1

1. YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-YMEL1 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >2 publications with YMEL1 and Atrophy

Organs/Tissues associated with anti-YMEL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with YMEL1 and Brain
 Heart Antibodies  >1 publications with YMEL1 and Heart
 Pancreas Antibodies  >1 publications with YMEL1 and Pancreas
 Eye Antibodies  >1 publications with YMEL1 and Eye
 Kidney Antibodies  >1 publications with YMEL1 and Kidney
 Muscle Antibodies  >1 publications with YMEL1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with YMEL1 and Embryonic Tissue
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