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HSPA9 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175719

Description: Rabbit IgG polyclonal antibody for Stress-70 protein, mitochondrial(HSPA9) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.Background: HSPA9(heat shock 70kDa protein 9(mortalin)), also known as GRP75, mot-2, mthsp75,… More details

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Product Overview

Online Datasheet in PDF
Product Name
Grp75 (HSPA9), Polyclonal Antibody
Full Product Name
Anti-Grp75 antibody
Product Gene Name
anti-HSPA9 antibody
Product Synonym Names
Stress-70 protein, mitochondrial; heat shock 70kDa protein 9(mortalin); 75 kDa glucose regulated protein antibody; 75 kDa glucose-regulated protein antibody; CSA antibody; Glucose Regulated Protein antibody; Grp 75 antibody; GRP-75 antibody; GRP75 antibody; GRP75_HUMAN antibody; Heat shock 70 kDa protein 9 antibody; Heat shock 70kD protein 9 antibody; heat shock 70kDa protein 9 antibody; Heat shock 70kDa protein 9B antibody; Heat shock protein 74 kDa A antibody; Heat shock protein A antibody; Heat shock protein cognate 74 antibody; Hsc74 antibody; Hsp74 antibody; Hsp74a antibody; HSPA9 antibody; Hspa9a antibody; HSPA9B antibody; MGC4500 antibody; mitochondrial antibody; Mortalin 2 antibody; Mortalin antibody; Mortalin perinuclear antibody; Mortalin2 antibody; MOT 2 antibody; MOT antibody; MOT2 antibody; Mthsp70 antibody; p66 mortalin antibody; P66 MOT antibody; PBP74 antibody; Peptide binding protein 74 antibody; Peptide-binding protein 74 antibody; Stress 70 protein mitochondrial antibody; Stress 70 protein mitochondrial precursor antibody; Stress-70 protein antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
73,680 Da
OMIM
600548
3D Structure
ModBase 3D Structure for P38646
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Grp75 (591-609aa DTETKMEEFKDQLPADECN), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-HSPA9 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC

Western Blot (WB) of anti-HSPA9 antibody

Anti-Grp75 antibody, MBS175719, Western blotting
All lanes: Anti Grp75 (MBS175719) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: A549 Whole Cell Lysate at 40ug
Lane 3: 293T Whole Cell Lysate at 40ug
Lane 4: M431 Whole Cell Lysate at 40ug
Lane 5: COLO320 Whole Cell Lysate at 40ug
Predicted bind size: 74KD
Observed bind size: 74KD
Rabbit Anti-HSPA9 Polyclonal Antibody – Cat# MBS175719

Immunohistochemistry (IHC) of anti-HSPA9 antibody

Anti-Grp75 antibody, MBS175719, IHC(P)
IHC(P): Human Lung Cancer Tissue
Rabbit Anti-HSPA9 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175719

Immunohistochemistry (IHC) of anti-HSPA9 antibody

Anti-Grp75 antibody, MBS175719, IHC(P)
IHC(P): Rat Liver Tissue
Rabbit Anti-HSPA9 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175719

Immunocytochemistry (ICC) of anti-HSPA9 antibody

Anti-Grp75 antibody, MBS175719, ICC
ICC: A549 Cell
Rabbit Anti-HSPA9 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS175719

Other Notes

Small volumes of anti-HSPA9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPA9 purchase

MBS175719 is an antibody targeting HSPA9. Also known as Anti-Grp75 antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPA9. It may not necessarily be applicable to this product.

NCBI GI #
21264428
NCBI GeneID
3313
NCBI Accession #
P38646.2
UniProt Primary Accession #
P38646
UniProt Secondary Accession #
P30036; P31932; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56; B2RCM1
UniProt Related Accession #
P38646
NCBI Official Full Name
Stress-70 protein, mitochondrial
NCBI Official Synonym Full Names
heat shock 70kDa protein 9 (mortalin)
NCBI Official Symbol
HSPA9
NCBI Official Synonym Symbols
CSA; MOT; MOT2; CRP40; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; HEL-S-124m
UniProt Protein Name
Stress-70 protein, mitochondrial
UniProt Synonym Protein Names
75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74
Protein Family
Stress-70 protein
UniProt Gene Name
HSPA9
UniProt Synonym Gene Names
GRP75; HSPA9B; mt-HSP70; GRP-75; MOT; PBP74
UniProt Entry Name
GRP75_HUMAN
NCBI Protein Information
stress-70 protein, mitochondrial; mortalin-2; p66-mortalin; mortalin, perinuclear; heat shock 70kD protein 9B; peptide-binding protein 74; 75 kDa glucose-regulated protein; catecholamine-regulated protein 40; epididymis secretory sperm binding protein Li 124m

NCBI Summary for HSPA9

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
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UniProt Comments for HSPA9

HSPA9B: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Belongs to the heat shock protein 70 family.

Protein type: Chaperone; Nucleolus; Heat shock protein

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: focal adhesion; mitochondrion; cytoplasm; nucleolus

Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding

Biological Process: cellular protein metabolic process; protein folding; protein export from nucleus; protein targeting to mitochondrion; negative regulation of apoptosis
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Research Articles on HSPA9

1. UBXN2A binds to mot-2 and releases sequestrated p53, which leads to p53- dependent apoptosis in colon cancer cells with high mot-2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HSPA9 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram

Diseases associated with anti-HSPA9 antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >11 publications with HSPA9 and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >7 publications with HSPA9 and Brain Diseases
 Nervous System Diseases Antibodies  >7 publications with HSPA9 and Nervous System Diseases
 Immune System Diseases Antibodies  >5 publications with HSPA9 and Immune System Diseases
 Parkinson Disease Antibodies  >4 publications with HSPA9 and Parkinson Disease
 Cardiovascular Diseases Antibodies  >3 publications with HSPA9 and Cardiovascular Diseases
 Liver Diseases Antibodies  >3 publications with HSPA9 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with HSPA9 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with HSPA9 and Liver Neoplasms
 Lung Neoplasms Antibodies  >1 publications with HSPA9 and Lung Neoplasms

Organs/Tissues associated with anti-HSPA9 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with HSPA9 and Blood
 Liver Antibodies  >7 publications with HSPA9 and Liver
 Brain Antibodies  >7 publications with HSPA9 and Brain
 Lung Antibodies  >5 publications with HSPA9 and Lung
 Bone Antibodies  >5 publications with HSPA9 and Bone
 Skin Antibodies  >4 publications with HSPA9 and Skin
 Bone Marrow Antibodies  >3 publications with HSPA9 and Bone Marrow
 Mouth Antibodies  >2 publications with HSPA9 and Mouth
 Muscle Antibodies  >2 publications with HSPA9 and Muscle
 Connective Tissue Antibodies  >2 publications with HSPA9 and Connective Tissue
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